Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 87, Issue 12, Pages 8203-8212Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c00432
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Funding
- National 1000 Talent Plan of China
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This study developed a chiral calcium phosphate-catalyzed enantioselective amination of 2-oxindoles with dibenzyl azodicarboxylate, resulting in consistently high yields and excellent enantioselectivity. This method features low catalyst loading and high catalytic efficiency, and its practical value is demonstrated through scale-up experiments and catalyst recovery and reuse trials.
A chiral calcium phosphate-catalyzed enantioselective amination of 2-oxindoles with dibenzyl azodicarboxylate has been developed, affording the products in consistently high yields and excellent enantioselectivity. This synthetic method features low catalyst loading and a high catalytic efficiency. Moreover, the practical value of this process is well demonstrated by a scale-up experiment and a trial of catalyst recovery and reuse.
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