Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 87, Issue 9, Pages 6418-6425Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c00275
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Funding
- Natural Science Foundation of Shandong Province [ZR2021MB136, ZR2018BB026]
- College Students Innovation and Entrepreneurship Training Project of China [202110446051]
- Doctoral Start-Up Scientific Research Foundation of Qufu Normal University
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A method for the rapid synthesis of polycyclic 3,3'-biindole derivatives has been developed using AgOTf-catalyzed nucleophilic addition and cycloisomerization processes. The reaction is efficient and takes only a few minutes, resulting in moderate to good yields of functionalized polycyclic 3,3'-biindoles.
A method for the rapid synthesis of polycyclic 3,3 '- biindole derivatives has been developed through AgOTf-catalyzed nucleophilic addition and cycloisomerization processes. The cascade reaction employs readily accessible indoles and their N2-formylphenyl derivatives and provides functionalized polycyclic 3,3 '-biindoles in moderate to good yields under mild conditions. This reaction is highly efficient and takes only several minutes (similar to 5 min). Notably, the method is also highlighted by a Selectfluormediated oxidation reaction that quickly generates the oxindole derivatives
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