Dearomative Iodocyclization of N-(o-Alkynyl)aryl Isoindole

We present a dearomative iodocyclization of N-(o-alkynyl)aryl isoindole here, which affords various biologically active benzoindoleazine skeletons containing alkenyl iodine. The products can further undergo cycloaddition or coupling reactions to afford a series of highly functionalized N-fused polycyclic scaffolds.

Automated summary

This paper presents a dearomative iodocyclization of N-(o-alkynyl)aryl isoindole, which leads to the formation of various biologically active benzoindoleazine skeletons containing alkenyl iodine. The resulting products can undergo further cycloaddition or coupling reactions to form a series of highly functionalized N-fused polycyclic scaffolds.