Cobalt-CatalyzedZtoEGeometrical Isomerization of 1,3-Dienes

An efficient cobalt-catalyzed geometrical isomerization of1,3-dienes is described. In the combination of a CoCl2precatalyst with anamido-diphosphine-oxazoline ligand, the geometrical isomerization ofE/Zmixtures of 1,3-dienes proceed in a stereoconvergent manner, affording (E)isomers in high stereoselectivity. This facile transformation features a broadsubstrate scope with good functional group tolerance and could be scaled up to the gram scale smoothly with a catalyst loading of 1mol %.

Automated summary

An efficient cobalt-catalyzed geometrical isomerization of 1,3-dienes is described, where the combination of a CoCl2 precatalyst and anamido-diphosphine-oxazoline ligand enables stereoconvergent conversion of E/Z mixtures of 1,3-dienes to (E) isomers in high stereoselectivity. This method features broad substrate scope, good functional group tolerance, and can be scaled up to gram scale with low catalyst loading.