Transition-Metal-Free O-Arylation of Alcohols and Phenols withS-Arylphenothiaziniums

Herein, we report the transition-metal-free O-arylation of alcoholsand phenols withS-arylphenothiaziniums, which can be easily synthesized fromboronic acids. Aryl substituents derived from arylboronic acids were selectivelyintroduced into the hydroxy groups in alcohols and phenols, and a variety of arylethers were synthesized. This selectivity is supported by theoretical calculations

Automated summary

Here, we report a transition-metal-free O-arylation reaction of alcohols and phenols using S-arylphenothiaziniums, which can be easily synthesized from boronic acids. Aryl substituents derived from arylboronic acids were selectively introduced into the hydroxy groups in alcohols and phenols, resulting in the synthesis of various aryl ethers. The selectivity of this reaction is supported by theoretical calculations.