Journal
CANCER CELL
Volume 27, Issue 4, Pages 437-438Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2015.03.015
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Adaptive immune resistance ablates effective anti-tumor immune responses. In a recent issue of Nature, Victor and colleagues describe that anti-PD-L1 combats adaptive immune resistance upon localized radiation plus anti-CTLA-4 therapy. The superior activity of radiation and dual immune checkpoint blockade is mediated by non-redundant immune mechanisms in cancer.
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