Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 63, Issue 12, Pages 1887-1890Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.122.263902
Keywords
oncology; head and neck; FDG PET; CT; head and neck cancer; staging
Funding
- National Cancer Institute [U01 CA079778, U01 CA080098, CA180820, CA180794]
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This study is the first multicenter clinical trial to report inter-observer agreement of 18F-FDG PET/CT scans for staging of clinical N0 neck in head and neck cancer, with high negative predictive value.
To our knowledge, no prior multicenter clinical trial has reported inter -observer agreement of 18F-FDG PET/CT scans for staging of clinical N0 neck in head and neck cancer. Methods: A total of 287 participants were recruited. For visual analysis, positive nodal uptake of 18F-FDG was defined as uptake visually greater than activity seen in the blood pool. Results: The negative predictive value of the 18F-FDG PET/CT for N0 clinical neck was 86% or above for visual assessment (95% CI, 86%-88%) for the 2 central readers and above 90% (95% CI, 90%-95%) for SUVmaxfor central reads and site reads dichotomized at the optimal cutoff value of 1.8 and the prespecified cutoff value of 3.5, respectively. The K coefficients between the 2 expert readers and between central reads and site reads varied between 0.53 and 0.78. Conclusion: The NPV of the 18F-FDG PET/CT for N0 clinical neck was 86% or above for visual assessment and above 90% for SUVmax cut points of 1.8 and 3.5 with moderate to substantial agreements.
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