Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 100, Issue 7, Pages 1476-1486Publisher
WILEY
DOI: 10.1002/jnr.25048
Keywords
Fukuda; hippocampus; International Consensus Criteria; memory; myalgic encephalomyelitis; chronic fatigue syndrome
Categories
Funding
- Stafford Fox Medical Research Foundation [216285HTCF2]
- Judith Jane Mason and Harold Stannett Williams Memorial Foundation [MAS2015F024]
- Blake-Beckett Foundation [4579]
- Buxton Foundation [22065100000]
- McCusker Charitable Foundation [22048500000]
- [22042000000]
- [22063300000]
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This study found that hippocampal subfield volumes are associated with cognitive and memory problems in ME/CFSICC patients, but not in ME/CFSFukuda patients. ME/CFSICC patients have larger subfield volumes, which are strongly correlated with clinical measures.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients suffer from a cognitive and memory dysfunction. Because the hippocampus plays a key role in both cognition and memory, we tested for volumetric differences in the subfields of the hippocampus in ME/CFS. We estimated hippocampal subfield volumes for 25 ME/CFS patients who met Fukuda criteria only (ME/CFSFukuda), 18 ME/CFS patients who met the stricter ICC criteria (ME/CFSICC), and 25 healthy controls (HC). Group comparisons with HC detected extensive differences in subfield volumes in ME/CFSICC but not in ME/CFSFukuda. ME/CFSICC patients had significantly larger volume in the left subiculum head (p < 0.001), left presubiculum head (p = 0.0020), and left fimbria (p = 0.004). Correlations of hippocampus subfield volumes with clinical measures were stronger in ME/CFSICC than in ME/CFSFukuda patients. In ME/CFSFukuda patients, we detected positive correlations between fatigue and hippocampus subfield volumes and a negative correlation between sleep disturbance score and the right CA1 body volume. In ME/CFSICC patients, we detected a strong negative relationship between fatigue and left hippocampus tail volume. Strong negative relationships were also detected between pain and SF36 physical scores and two hippocampal subfield volumes (left: GC-ML-DG head and CA4 head). Our study demonstrated that volumetric differences in hippocampal subfields have strong statistical inference for patients meeting the ME/CFSICC case definition and confirms hippocampal involvement in the cognitive and memory problems of ME/CFSICC patients.
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