Related references
Note: Only part of the references are listed.The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)
Sarah L. Boddy et al.
BMC MEDICINE (2021)
Validation of Induced Microglia-Like Cells (iMG Cells) for Future Studies of Brain Diseases
Atoshi Banerjee et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2021)
Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure
Steven D. Sheridan et al.
TRANSLATIONAL PSYCHIATRY (2021)
Microglia Activation in Basal Ganglia Is a Late Event in Huntington Disease Pathophysiology
Natalia P. Rocha et al.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2021)
Amyotrophic lateral sclerosis is a systemic disease: peripheral contributions to inflammation-mediated neurodegeneration
Stanley H. Appel et al.
CURRENT OPINION IN NEUROLOGY (2021)
A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA)
Michelle K. Lupton et al.
NEUROIMAGE-CLINICAL (2021)
TDP-43 proteinopathies: a new wave of neurodegenerative diseases
Eva Maria Johanna de Boer et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)
Temporal evolution of the microbiome, immune system and epigenome with disease progression in ALS mice
Claudia Figueroa-Romero et al.
DISEASE MODELS & MECHANISMS (2020)
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins
Vandana Deora et al.
GLIA (2020)
Modeling cell-autonomous motor neuron phenotypes in ALS using iPSCs
James Hawrot et al.
NEUROBIOLOGY OF DISEASE (2020)
ALS-derived fibroblasts exhibit reduced proliferation rate, cytoplasmic TDP-43 aggregation and a higher susceptibility to DNA damage
Javier Riancho et al.
JOURNAL OF NEUROLOGY (2020)
Addressing heterogeneity in amyotrophic lateral sclerosis CLINICAL TRIALS
Namita A. Goyal et al.
MUSCLE & NERVE (2020)
Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery
Lotta E. Oikari et al.
STEM CELL REPORTS (2020)
Increased activation ability of monocytes from ALS patients
Yunlan Du et al.
EXPERIMENTAL NEUROLOGY (2020)
A characterization of the molecular phenotype and inflammatory response of schizophrenia patient-derived microglia-like cells
Paul R. Ormel et al.
BRAIN BEHAVIOR AND IMMUNITY (2020)
Motor cortex transcriptome reveals microglial key events in amyotrophic lateral sclerosis
Oriol Dols-Icardo et al.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2020)
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
Chien-Hsiung Yu et al.
CELL (2020)
Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations
Anna Konopka et al.
MOLECULAR NEURODEGENERATION (2020)
The role of TDP-43 mislocalization in amyotrophic lateral sclerosis
Terry R. Suk et al.
MOLECULAR NEURODEGENERATION (2020)
The microglial component of amyotrophic lateral sclerosis
Benjamin E. Clarke et al.
BRAIN (2020)
Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis
Raquel B. McGill et al.
BRAIN COMMUNICATIONS (2020)
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
Joy Mitra et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
Archana Prasad et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)
The debated toxic role of aggregated TDP-43 in amyotrophic lateral sclerosis: a resolution in sight?
Rudolf C. Hergesheimer et al.
BRAIN (2019)
Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases
Theodore S. Kapellos et al.
FRONTIERS IN IMMUNOLOGY (2019)
Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia
Oliver H. Tam et al.
CELL REPORTS (2019)
Fluorescence-based quantification of nucleocytoplasmic transport
Joshua B. Kelley et al.
METHODS (2019)
Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons
Adam J. Svahn et al.
ACTA NEUROPATHOLOGICA (2018)
Integrated magnetic resonance imaging and [11C]-PBR28 positron emission tomographic imaging in amyotrophic lateral sclerosis
Mohamad J. Alshikho et al.
ANNALS OF NEUROLOGY (2018)
Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications
Ruth Chia et al.
LANCET NEUROLOGY (2018)
Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ
Kimberly Young et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2018)
The Kaleidoscope of Microglial Phenotypes
Marissa L. Dubbelaar et al.
FRONTIERS IN IMMUNOLOGY (2018)
Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors
C. M. Sellgren et al.
MOLECULAR PSYCHIATRY (2017)
Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP-43 subcellular distribution
G. De Marco et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2017)
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss
Rosa C. Paolicelli et al.
NEURON (2017)
An environment-dependent transcriptional network specifies human microglia identity
David Gosselin et al.
SCIENCE (2017)
A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants
Katie J. Ryan et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes
Weihua Zhao et al.
JAMA NEUROLOGY (2017)
Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic implications
Jia Liu et al.
FRONTIERS IN IMMUNOLOGY (2017)
Massive transcriptome sequencing of human spinal cord tissues provides new insights into motor neuron degeneration in ALS
Anna Maria D'Erchia et al.
SCIENTIFIC REPORTS (2017)
Peripheral monocytes are functionally altered and invade the CNS in ALS patients
Lisa Zondler et al.
ACTA NEUROPATHOLOGICA (2016)
Comparative morphometric analysis of microglia in the spinal cord of SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis
Tomohiro Ohgomori et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2016)
Characterizing Primary Human Microglia: A Comparative Study with Myeloid Subsets and Culture Models
J. Melief et al.
GLIA (2016)
In-situ expression of Interleukin-18 and associated mediators in the human brain of sALS patients: Hypothesis for a role for immune-inflammatory mechanisms
Hazim Kadhim et al.
MEDICAL HYPOTHESES (2016)
In vitro prion-like behaviour of TDP-43 in ALS
Phillip Smethurst et al.
NEUROBIOLOGY OF DISEASE (2016)
New tools for studying microglia in the mouse and human CNS
Mariko L. Bennett et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
TDP-43 activates microglia through NF-κB and NLRP3 inflammasome
Weihua Zhao et al.
EXPERIMENTAL NEUROLOGY (2015)
NLRP3 Inflammasome Is Expressed by Astrocytes in the SOD1 Mouse Model of ALS and in Human Sporadic ALS Patients
Sonja Johann et al.
GLIA (2015)
TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord
Johannes Brettschneider et al.
ACTA NEUROPATHOLOGICA (2014)
Glial cells in amyotrophic lateral sclerosis
T. Philips et al.
EXPERIMENTAL NEUROLOGY (2014)
State of play in amyotrophic lateral sclerosis genetics
Alan E. Renton et al.
NATURE NEUROSCIENCE (2014)
Identification of a unique TGF-β dependent molecular and functional signature in microglia
Oleg Butovsky et al.
NATURE NEUROSCIENCE (2014)
Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease
Masahiro Ohgidani et al.
SCIENTIFIC REPORTS (2014)
Innate immune activation in neurodegenerative disease
Michael T. Heneka et al.
NATURE REVIEWS IMMUNOLOGY (2014)
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
Katrin Kierdorf et al.
NATURE NEUROSCIENCE (2013)
Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK
Barbara Meyer et al.
NUCLEIC ACIDS RESEARCH (2013)
A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
Isaac M. Chiu et al.
CELL REPORTS (2013)
Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis
Johannes Brettschneider et al.
ACTA NEUROPATHOLOGICA (2012)
Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS
Bing Liao et al.
EXPERIMENTAL NEUROLOGY (2012)
Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
Oleg Butovsky et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Regulation of Postnatal Forebrain Amoeboid Microglial Cell Proliferation and Development by the Transcription Factor Runx1
Morena Zusso et al.
JOURNAL OF NEUROSCIENCE (2012)
Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis
Johannes Brettschneider et al.
PLOS ONE (2012)
Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis
Philippe Corcia et al.
PLOS ONE (2012)
Cytoplasmic accumulation of TDP-43 in circulating lymphomonocytes of ALS patients with and without TARDBP mutations
Giovanni De Marco et al.
ACTA NEUROPATHOLOGICA (2011)
Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice
David R. Beers et al.
BRAIN BEHAVIOR AND IMMUNITY (2011)
Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis
David J. Graber et al.
JOURNAL OF NEUROINFLAMMATION (2010)
Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies
Ping Jin et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2010)
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Florent Ginhoux et al.
SCIENCE (2010)
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies
Manuela Neumann et al.
ACTA NEUROPATHOLOGICA (2009)
Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis
J. Kuhle et al.
EUROPEAN JOURNAL OF NEUROLOGY (2009)
Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia
Fumiaki Mori et al.
ACTA NEUROPATHOLOGICA (2008)
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Masato Hasegawa et al.
ANNALS OF NEUROLOGY (2008)
ALSFRS-R score and its ratio: A useful predictor for ALS-progression
Katja Kollewe et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2008)
Elevated inflammatory markers in a group of amyotrophic lateral sclerosis patients from Northern India
G. Nagesh Babu et al.
NEUROCHEMICAL RESEARCH (2008)
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
T. Fernandes-Alnemri et al.
CELL DEATH AND DIFFERENTIATION (2007)
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
Ian R. A. Mackenzie et al.
ANNALS OF NEUROLOGY (2007)
TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions
Manuela Neumann et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)
Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: Mechanisms of mitochondriopathy and cell death
Lee J. Martin et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2007)
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Tetsuaki Arai et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
A guided tour into subcellular colocalization analysis in light microscopy
S. Bolte et al.
JOURNAL OF MICROSCOPY (2006)
Genetics of familial and sporadic amyotrophic lateral sclerosis
Francois Gros-Louis et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2006)
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Manuela Neumann et al.
SCIENCE (2006)
MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS)
Rongzhen Zhang et al.
JOURNAL OF NEUROIMMUNOLOGY (2006)
Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS
F Kimura et al.
NEUROLOGY (2006)
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
A Nimmerjahn et al.
SCIENCE (2005)
Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)
RZ Zhang et al.
JOURNAL OF NEUROIMMUNOLOGY (2005)
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis:: an [11C](R)-PK11195 positron emission tomography study
MR Turner et al.
NEUROBIOLOGY OF DISEASE (2004)
Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
JS Henkel et al.
ANNALS OF NEUROLOGY (2004)
Inflammatory processes in amyotrophic lateral sclerosis
PL McGeer et al.
MUSCLE & NERVE (2002)
Immune reactivity in a mouse model of familial ALS correlates with disease progression
ME Alexianu et al.
NEUROLOGY (2001)