Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 367, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2022.577849
Keywords
Neurosarcoidosis; Cytokines; Chemokines; Vascular angiogenesis; Vascular injury; Biomarkers; Neurosarcoidosis; Cytokines; Chemokines; Vascular angiogenesis; Vascular injury; Biomarkers
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Neurosarcoidosis patients have significantly elevated levels of cytokines, chemokines, vascular angiogenesis, and vascular injury biomarkers in cerebrospinal fluid (CSF) and plasma.
Methods: Cerebrospinal fluid (CSF) and plasma levels of 38 biomarkers from 20 neurosarcoidosis (NS) patients were compared to healthy controls (HC).Results: In CSF, 25 biomarkers were significantly elevated compared to HC: IFN gamma, TNF alpha, TNF beta, IL-2, IL-6, IL-10, IL-12B, IL-15, IL-16, CCL2, CCL3, CCL4, CCL11, CCL13, CCL17, CCL22, CCL26, CXCL8, CXCL10, TNFR2, VEGF-A, PIGF, SAA, VCAM1, and ICAM1. In plasma, 12 biomarkers were significantly elevated compared to HC: IFN gamma, TNF alpha, CCL2, CCL3, CCL4, CCL17, CXCL10, VEGFR1, PIGF, SAA, VCAM1, and ICAM1.Conclusion: NS patients have profoundly elevated cytokines, chemokines, vascular angiogenesis, and vascular injury biomarkers in CSF and plasma.
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