4.5 Review

Evolving management of HER2+breast cancer brain metastases and leptomeningeal disease

Related references

Note: Only part of the references are listed.
Article Oncology

The presentation of brain metastases in melanoma, non-small cell lung cancer, and breast cancer and potential implications for screening brain MRIs

Matthew N. Mills et al.

Summary: Breast cancer patients were younger, presented with advanced disease, required whole brain radiation therapy, and had poorer survival compared to NSCLC and melanoma patients.

BREAST CANCER RESEARCH AND TREATMENT (2022)

Article Oncology

Pyrotinib plus capecitabine for patients with human epidermal growth factor receptor 2-positive breast cancer and brain metastases (PERMEATE): a multicentre, single-arm, two-cohort, phase 2 trial

Min Yan et al.

Summary: This study investigated the activity and safety of pyrotinib plus capecitabine in patients with HER2-positive metastatic breast cancer and brain metastases. The combination therapy showed a high intracranial objective response rate in patients who had not received radiotherapy and had acceptable safety profiles.

LANCET ONCOLOGY (2022)

Article Oncology

Clinical trial of proton craniospinal irradiation for leptomeningeal metastases

T. Jonathan Yang et al.

Summary: Proton craniospinal irradiation is a safe treatment for patients with leptomeningeal metastases from solid tumors, with durable disease control observed in some patients.

NEURO-ONCOLOGY (2021)

Article Oncology

Hippocampal avoidance whole-brain radiotherapy without memantine in preserving neurocognitive function for brain metastases: a phase II blinded randomized trial

Wen-Chi Yang et al.

Summary: This study found that patients with brain metastases undergoing hippocampal avoidance whole-brain radiotherapy (HA-WBRT) showed better preservation of memory function at 6-month follow-up compared to those receiving conformal WBRT. However, there were no significant differences in verbal fluency and executive function.

NEURO-ONCOLOGY (2021)

Article Oncology

Final Efficacy Results of Neratinib in HER2-positive Hormone Receptor-positive Early-stage Breast Cancer From the Phase III ExteNET Trial

Arlene Chan et al.

Summary: In early-stage breast cancer patients, neratinib provides a 5.1% increase in invasive disease-free survival and a 2.1% increase in overall survival at 8 years compared to placebo. For patients with residual disease after neoadjuvant therapy, the absolute benefits of neratinib are 7.4% and 9.1%, respectively.

CLINICAL BREAST CANCER (2021)

Article Oncology

Nivolumab and Stereotactic Radiosurgery for Patients With Breast Cancer Brain Metastases: A Nonrandomized, Open-Label Phase 1b Study

Kamran A. Ahmed et al.

Summary: The study investigated the feasibility and efficacy of treatment with nivolumab and stereotactic radiosurgery (SRS) in patients with metastatic breast cancer brain metastases. Results indicated that this combination therapy could improve intracranial tumor control rates and was well tolerated by patients.

ADVANCES IN RADIATION ONCOLOGY (2021)

Article Oncology

Prognostic validation and clinical implications of the EANO ESMO classification of leptomeningeal metastasis from solid tumors

Emilie Le Rhun et al.

Summary: This study retrospectively analyzed data from 254 patients with leptomeningeal metastases from solid tumors and found that patients with confirmed LM had worse outcomes compared to those with probable or possible LM. Different subtypes of LM had varying prognoses, with nodular disease on MRI negatively impacting outcomes for type II LM patients.

NEURO-ONCOLOGY (2021)

Review Oncology

The incidence of brain metastases among patients with metastatic breast cancer: a systematic review and meta-analysis

Markus Kuksis et al.

Summary: The study showed high incidence of brain metastases among patients with HER2+ and triple negative MBC, with lower incidence among patients with HR+/HER2- MBC. Further investigation is needed to assess the utility of brain metastases screening programs in these populations.

NEURO-ONCOLOGY (2021)

Article Multidisciplinary Sciences

Phase II study of ipilimumab and nivolumab in leptomeningeal carcinomatosis

Priscilla K. Brastianos et al.

Summary: A single-arm Phase II study of 18 patients with leptomeningeal disease (LMD) receiving combined ipilimumab and nivolumab showed promising activity with acceptable safety profile. Larger multicenter clinical trials are needed to validate these results for the rare complication with a very poor prognosis.

NATURE COMMUNICATIONS (2021)

Article Oncology

Pertuzumab Plus High-Dose Trastuzumab in Patients With Progressive Brain Metastases and HER2-Positive Metastatic Breast Cancer: Primary Analysis of a Phase II Study

Nancy U. Lin et al.

Summary: The study aimed to investigate the efficacy of high-dose trastuzumab in treating HER2-positive MBC patients with CNS metastases. Although the CNS ORR was modest, 68% of patients experienced clinical benefit, suggesting that further study is warranted.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Breast cancer subtype predicts clinical outcomes after stereotactic radiation for brain metastases

Matthew N. Mills et al.

Summary: The study investigated the prognostic ability of tumor subtype for patients with breast cancer brain metastases (BCBM) treated with stereotactic radiation (SRT). It found that tumor subtype is prognostic for overall survival (OS) and distant intracranial control (DIC) for these patients.

JOURNAL OF NEURO-ONCOLOGY (2021)

Article Oncology

Safety and efficacy of the combination of nivolumab plus ipilimumab in patients with melanoma and asymptomatic or symptomatic brain metastases (CheckMate 204)

Hussein A. Tawbi et al.

Summary: The combination of nivolumab and ipilimumab shows durable clinical benefit for asymptomatic patients with melanoma brain metastases, but has limited activity in patients with neurological symptoms and/or requiring corticosteroids.

NEURO-ONCOLOGY (2021)

Review Oncology

Prognostic factors of brain metastasis and survival among HER2-positive metastatic breast cancer patients: a systematic literature review

Michelle D. Hackshaw et al.

Summary: Patients with HER2+ breast cancer who develop brain metastasis typically have poor prognosis. Factors such as younger age, hormone receptor status, tumor size and treatment regimens can affect time to brain metastasis diagnosis and survival after diagnosis. Combination therapies including trastuzumab and lapatinib or trastuzumab and pertuzumab show promise in improving survival in these patients. More research is needed to understand risk factors for brain metastasis and improve treatment options.

BMC CANCER (2021)

Article Oncology

Pyrotinib Treatment in Patients With HER2-positive Metastatic Breast Cancer and Brain Metastasis: Exploratory Final Analysis of Real-World, Multicenter Data

Munawar Anwar et al.

Summary: Pyrotinib has shown promising antitumor activity in HER2-positive metastatic breast cancer, especially in patients with brain metastasis. The combination of surgical or radiotherapy with pyrotinib statistically improves overall survival in this cohort. Tumor mutation burden may be a potential biomarker for predicting progression-free and overall survival, but further verification is needed for clinical application.

CLINICAL CANCER RESEARCH (2021)

Article Oncology

Efficacy of Neratinib Plus Capecitabine in the Subgroup of Patients with Central Nervous System Involvement from the NALA Trial

Sara A. Hurvitz et al.

Summary: The study found that in patients with HER2-positive breast cancer metastases, the combination therapy of neratinib plus capecitabine significantly improved progression-free survival and central nervous system outcomes compared to lapatinib plus capecitabine.

ONCOLOGIST (2021)

Article Oncology

Breast cancer patients treated with intrathecal therapy for leptomeningeal metastases in a large real-life database

M. Carausu et al.

Summary: Leptomeningeal metastasis is a rare and dangerous complication of metastatic breast cancer. Patients treated with intrathecal therapy usually have poor prognosis, but a subgroup of patients may have better outcomes when concomitant systemic therapy and methotrexate are used.

ESMO OPEN (2021)

Article Oncology

Stereotactic Radiosurgery for Resected Brain Metastases: Single-Institutional Experience of Over 500 Cavities

Siyu Shi et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2020)

Review Oncology

Management of brain metastases in breast cancer: a review of current practices and emerging treatments

Matthew N. Mills et al.

BREAST CANCER RESEARCH AND TREATMENT (2020)

Article Medicine, General & Internal

Pembrolizumab for Early Triple-Negative Breast Cancer

Peter Schmid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer

R. K. Murthy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer

Shanu Modi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Oncology

Molecular and cellular mechanisms underlying brain metastasis of breast cancer

Mari Hosonaga et al.

CANCER AND METASTASIS REVIEWS (2020)

Review Biochemistry & Molecular Biology

Management of Brain and Leptomeningeal Metastases from Breast Cancer

Alessia Pellerino et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Oncology

ctDNA as a cancer biomarker: A broad overview

Luciana Santos Pessoa et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

Article Oncology

Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets

Damir Vareslija et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

Article Oncology

Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets

Damir Vareslija et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

Review Oncology

Leptomeningeal carcinomatosis in patients with breast cancer

Maria Alice Franzoi et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2019)

Article Oncology

Initial SRS for Patients With 5 to 15 Brain Metastases: Results of a Multi-Institutional Experience

Ryan T. Hughes et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2019)

Review Oncology

Breast leptomeningeal disease: a review of current practices and updates on management

Nicholas B. Figura et al.

BREAST CANCER RESEARCH AND TREATMENT (2019)

Review Oncology

Novel methods to diagnose leptomeningeal metastases in breast cancer

Lindsay Angus et al.

NEURO-ONCOLOGY (2019)

Article Medicine, General & Internal

Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer

G. von Minckwitz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Oncology

EpCAM-based assays for epithelial tumor cell detection in cerebrospinal fluid

Mark T. J. van Bussel et al.

JOURNAL OF NEURO-ONCOLOGY (2018)

Article Oncology

Predicting Brain Metastasis in Breast Cancer Patients: Stage Versus Biology

Hamdy A. Azim et al.

CLINICAL BREAST CANCER (2018)

Article Oncology

Molecular subtype predicts incidence and prognosis of brain metastasis from breast cancer in SEER database

Yi-Jun Kim et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2018)

Article Medicine, General & Internal

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain

Hussein A. Tawbi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Clinical Neurology

Preoperative Stereotactic Radiosurgery for Brain Metastases

David M. Routman et al.

FRONTIERS IN NEUROLOGY (2018)

Article Oncology

Leptomeningeal metastases: a RANO proposal for response criteria

Marc Chamberlain et al.

NEURO-ONCOLOGY (2017)

Article Oncology

Surgical Resection of Brain Metastases and the Risk of Leptomeningeal Recurrence in Patients Treated With Stereotactic Radiosurgery

Matthew D. Johnson et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2016)

Article Oncology

Leptomeningeal disease following stereotactic radiosurgery for brain metastases from breast cancer

Daniel M. Trifiletti et al.

JOURNAL OF NEURO-ONCOLOGY (2015)

Article Medicine, General & Internal

Pertuzumab, Trastuzumab, and Docetaxel in HER2-Positive Metastatic Breast Cancer

Sandra M. Swain et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Multidisciplinary Sciences

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

Leticia De Mattos-Arruda et al.

NATURE COMMUNICATIONS (2015)

Review Oncology

Leptomeningeal disease and breast cancer: the importance of tumor subtype

Sausan Abouharb et al.

BREAST CANCER RESEARCH AND TREATMENT (2014)

Article Medicine, Research & Experimental

Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice

Liufu Deng et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Oncology

CSF CA 15-3 in breast cancer-related leptomeningeal metastases

Emilie Le Rhun et al.

JOURNAL OF NEURO-ONCOLOGY (2014)

Review Oncology

Epilepsy meets cancer: when, why, and what to do about it?

Michael Weller et al.

LANCET ONCOLOGY (2012)

Article Medicine, General & Internal

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

Sunil Verma et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Chemistry, Multidisciplinary

Lapatinib Distribution in HER2 Overexpressing Experimental Brain Metastases of Breast Cancer

Kunal S. Taskar et al.

PHARMACEUTICAL RESEARCH (2012)

Article Clinical Neurology

Incidence and Risk Factors for Leptomeningeal Carcinomatosis in Breast Cancer Patients with Parenchymal Brain Metastases

Jong-myung Jung et al.

JOURNAL OF KOREAN NEUROSURGICAL SOCIETY (2012)

Article Oncology

Survival of breast cancer patients with meningeal carcinomatosis

H. Gauthier et al.

ANNALS OF ONCOLOGY (2010)

Article Oncology

Nomogram to Predict Subsequent Brain Metastasis in Patients With Metastatic Breast Cancer

Olivier Graesslin et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

Article Medical Laboratory Technology

Intrathecal synthesis of tumor markers is a highly sensitive test in the diagnosis of leptomeningeal metastasis from solid cancers

Elena Corsini et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2009)

Article Medicine, General & Internal

Lapatinib plus capecitabine for HER2-positive advanced breast cancer

Charles E. Geyer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Clinical Neurology

EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force

R. Soffietti et al.

EUROPEAN JOURNAL OF NEUROLOGY (2006)

Article Clinical Neurology

Ventriculoperitoneal shunt in patients with leptomeningeal metastasis

AMP Omuro et al.

NEUROLOGY (2005)

Review Biochemistry & Molecular Biology

Molecular mechanisms underlying ErbB2/HER2 action in breast cancer

D Harari et al.

ONCOGENE (2000)