Journal
JOURNAL OF NATURAL PRODUCTS
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.1c01051
Keywords
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Funding
- BMBF German-Indonesian cooperation project NAbaUnAk [16GW0124K]
- Baden-WurttembergStiftung [BWST_WSF-035]
- RISETPro scholarship program from the Indonesian Ministry for Research and Technology [8245-ID]
- German Academic Exchange Service (DAAD) [PKZ 91609054]
- German Center for Infection Research (DZIF) [TTU 09.818]
- BMBF (Gram-NEG design)
- German Research Foundation (DFG), TRR261 [398967434]
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A chemical investigation of the Indonesian strain Streptomyces sp. SHP 22-7 led to the discovery of three new pyrimidine nucleosides and several known analogues, some of which exhibited antimycobacterial and cytotoxic properties.
A chemical reinvestigation of the Indonesian strain Streptomyces sp. SHP 22-7 led to the isolation of three new pyrimidine nucleosides, along with six known analogues and zincphyrin. The structures of the new compounds (6, 7, 10) were elucidated by employing spectroscopic techniques (NMR, MS, CD, and IR) as well as enantioselective analyses of methyl branched side chain configurations. Application of the precursor-directed feeding approach led to the production and partial isolation of nine further pyrimidine analogues. The new compounds 6, 7, and 11 and three of the known compounds (2-4) were found to possess antimycobacterial and cytotoxic properties.
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