Journal
JOURNAL OF NATURAL PRODUCTS
Volume 85, Issue 3, Pages 657-665Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.2c00015
Keywords
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Funding
- ICBG grant from the NIH [U19-TW007401]
- The Nahmias-Schinazi Chair Fund at Emory University
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This article reports the antiviral activities of three marine natural products against SARS-CoV-2. These compounds can inhibit viral replication and may serve as promising candidates for novel drug leads.
Since early 2020, disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, causing millions of infections and deaths worldwide. Despite rapid deployment of effective vaccines, it is apparent that the global community lacks multipronged interventions to combat viral infection and disease. A major limitation is the paucity of antiviral drug options representing diverse molecular scaffolds and mechanisms of action. Here we report the antiviral activities of three distinct marine natural products.homofascaplysin A (1), (+)-aureol (2), and bromophycolide A (3). evidenced by their ability to inhibit SARS-CoV-2 replication at concentrations that are nontoxic toward human airway epithelial cells. These compounds stand as promising candidates for further exploration toward the discovery of novel drug leads against SARS-CoV-2.
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