Self-association synthesis with ortho-vanillin to promote mono- and heptanuclear complexes and their evaluation as antioxidant agents

This study describes the synthesis, crystal structure, antioxidant activity, and molecular modeling calculations for two Cu-II complexes obtained from the condensation of ortho-vanillin with furfurylamine. Both complexes catalyzed superoxide dismutation and were evaluated and quantified by nitro blue tetrazolium photoreduction, efficiently demonstrating McCord-Fridovich constant values from 5.50 to 2.87 x 10(6) (M(-1)s(-1)) in the 1.3-1.4 mu M range and an aqueous solution of pH 7.8. Despite an unusual arrangement containing seven Cu-II cations obtained by self-association processes, the heptamer, proportionally speaking, did not show multiplicative activity as initially expected. This situation was also evaluated using molecular docking. (c) 2022 Elsevier B.V. All rights reserved.

Automated summary

This study describes the synthesis, crystal structure, antioxidant activity, and molecular modeling calculations for two Cu-II complexes obtained from the condensation of ortho-vanillin with furfurylamine. Both complexes catalyzed superoxide dismutation and were evaluated and quantified by nitro blue tetrazolium photoreduction. Despite the unusual arrangement of the heptamer, it did not show the expected multiplicative activity.