Design and synthesis of novel urea derivatives of pyrimidine-pyrazoles as anticancer agents

Designed and synthesized a series of novel urea derivatives of pyrimidine-pyrazole, and screened for their anticancer activity. Compounds with (3,5-dinitro and 3,4,5-trimethoxy) substitution were exhibited more potent cytotoxicity than standard Etoposide. Molecular docking studies suggested that compounds were well occupied at the colchicine binding site and interacted with alpha, beta-tubuline interface of x-ray crystal structure of (PDB:1SA0), which demonstrates that synthesized compounds are promising tubulin inhibitors. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

A series of novel urea derivatives of pyrimidine-pyrazole were designed and synthesized, showing promising anticancer activity by targeting tubulin. Molecular docking studies indicated that these compounds could interact effectively with the tubulin interface, suggesting their potential as tubulin inhibitors.