Metal-free isocyanide insertion reaction to benzothiazolyl urea derivatives

A B S T R A C T An efficient iodine-catalyzed reaction of 2-aminobenzothiazole and isocyanides for the synthesis of benzothiazolyl urea derivatives via a metal-free isocyanide insertion reaction is reported. Introducing a simple method for the synthesis of desired benzothiazolyl urea skeletons and use of more acceptable iodine molecule instead of expensive transition metal catalysts are the most important advantages of this strategy.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

An efficient iodine-catalyzed reaction for the synthesis of benzothiazolyl urea derivatives via a metal-free isocyanide insertion reaction is reported in this study. The strategy offers the advantages of a simple synthesis method and the use of more affordable iodine catalyst instead of expensive transition metal catalysts.