Synthesis, crystal structure, spectroscopic characterization and anti-fungal activity of Ethyl 2-Oxo-2H-chromene-3-carboxylateDerivatives

Ethyl 2-oxo-2H-chromene-3-carboxylate derivatives were synthesized and characterized by FT-IR, NMR, MS and X-ray crystal diffraction. Compound 3d crystallizes in the triclinic system with space group P-1 . Compound 3e crystallizes in the monoclinic system with space group P2(1)/c . The potential anti-fungal activities have been studied against five kinds of common fungi at concentrations of 200 ppm and 500 ppm. The research showed that the target compounds exhibit certain anti-fungal activity against the tested fungal strains. The inhibition rate of compound 3b was the highest against Fusarium oxysporum, up to 60.29% at 500 ppm. Compound 3b is promising to become the lead compound of pesticide in the future, which is worthy of further study.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

Ethyl 2-oxo-2H-chromene-3-carboxylate derivatives were synthesized and evaluated for their antifungal activity. Compound 3b exhibited the highest inhibition rate against Fusarium oxysporum, showing promise as a potential lead compound for future pesticide development.