Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1257, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2022.132576
Keywords
Coumarin derivatives; Derivatives; Synthesis; Crystal structure; Spectral characterization; Anti-fungal activity
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Funding
- 13th Five-Year National Key Research Program of China [2017YFD0301604]
- National Natural Science Foundation of China [31960295, 32160660, 21562022]
- Natural Science Foundation of Jiangxi Province [20181BAB203015]
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Ethyl 2-oxo-2H-chromene-3-carboxylate derivatives were synthesized and evaluated for their antifungal activity. Compound 3b exhibited the highest inhibition rate against Fusarium oxysporum, showing promise as a potential lead compound for future pesticide development.
Ethyl 2-oxo-2H-chromene-3-carboxylate derivatives were synthesized and characterized by FT-IR, NMR, MS and X-ray crystal diffraction. Compound 3d crystallizes in the triclinic system with space group P-1 . Compound 3e crystallizes in the monoclinic system with space group P2(1)/c . The potential anti-fungal activities have been studied against five kinds of common fungi at concentrations of 200 ppm and 500 ppm. The research showed that the target compounds exhibit certain anti-fungal activity against the tested fungal strains. The inhibition rate of compound 3b was the highest against Fusarium oxysporum, up to 60.29% at 500 ppm. Compound 3b is promising to become the lead compound of pesticide in the future, which is worthy of further study.(c) 2022 Elsevier B.V. All rights reserved.
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