Notoginsenoids, a new class of hexa-nortriterpenoids from biotransformation of Panax notoginseng saponins

Notoginsenoids T1-T7, a new class of hexa-nortriterpenoids including two dimers and five monomers, possessing an unprecedented 9-en-5-ketone tricyclic hexa-nordammar skeleton and a variable side chain at C-17, were obtained from biotransformation of PPD-type dammarane saponins by the soil harvested with Panax notoginseng (Araliaceae), a famous traditional Chinese medicinal herb. Their structures were unambiguously determined by spectroscopic, single-crystal X-ray diffraction, Mo-2(AcO)(4)-induced CD and ECD analyzes. A plausible biotransformed pathway for T1-T7 was proposed. Notoginsenoids T1-T5 showed growth inhibitory effects on the probiotic and pathogenic fungi of P. notoginseng. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

Notoginsenoids T1-T7, a new class of hexa-nortriterpenoids obtained from the biotransformation of PPD-type dammarane saponins by soil harvested with Panax notoginseng, possess unique structures and show inhibitory effects on probiotic and pathogenic fungi of P. notoginseng.