A review on synthesis, mechanism of action, and structure-activity relationships of 1,2,3-triazole-based alpha-glucosidase inhibitors as promising anti-diabetic agents

alpha-Glucosidase is a key enzyme in hydrolysis of carbohydrates to glucose and located in the small intestine brush border. Inhibition of this enzyme delay the release of glucose and therefore alpha-glucosidase inhibitors are considered as attractive drugs for treatment of diabetes as a carbohydrate-related disorder. Due to the importance of alpha-glucosidase inhibitors in the treatment of diabetes, the discovery and development of new safe and efficient inhibitors for alpha-glucosidase is an attractive topic for medicinal chemists. In the last decade, 1,2,3-triazole-based derivatives have found much interest in this research field. The click reaction is the most potent tool for easy construction for synthesis of hybrid molecules of 1,2,3-triazole ring and other effective pharmacophors in alpha-glucosidase inhibition. Herein, an overview is reported on synthesis, biological evaluations, and structure-activity relationships of the reported alpha- glucosidase inhibitors containing 1,2,3-triazole ring.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

Alpha-glucosidase inhibitors play a crucial role in the treatment of diabetes, and 1,2,3-triazole-based derivatives have attracted much interest in this field. The click reaction is a potent tool for synthesizing hybrid molecules containing 1,2,3-triazole ring and other effective pharmacophors for alpha-glucosidase inhibition.