Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 434, Issue 10, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2022.167581
Keywords
replication stress response; DNA damage tolerance; ubiquitin ligase; fork regression; protein structure
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Funding
- Natural Science Foundation of China [31870769, 32071205, 32100980]
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This review provides insights into the multiple activities and coordination mechanisms of the budding yeast protein Rad5 and its orthologs, highlighting their critical roles in the cellular response to DNA replication stresses.
The budding yeast protein Rad5 is highly conserved among eukaryotes. Rad5 and its orthologs including helicase like transcription factor (HLTF) and SNF2 histone linker PHD RING helicase (SHPRH) in humans constitute a unique family of enzymes that play critical roles in the cellular response to DNA replication stresses. The function of the Rad5 family of enzymes is fulfilled by their multiple activities, including ubiquitin ligase, replication fork regression activities and others. Herein, we review recent studies that provided mechanistic insights into their multiple activities and their coordination. (C) 2022 Elsevier Ltd. All rights reserved.
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