Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 94, Issue 9, Pages 4156-4169Publisher
WILEY
DOI: 10.1002/jmv.27841
Keywords
COVID-19; heterogeneity; mean incubation time; meta-analysis; publication bias; sensitivity analysis
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada
- Canada Research Chairs Program
Ask authors/readers for more resources
Providing sensible estimates of the mean incubation time for COVID-19 is important yet complex. This study aims to provide synthetic estimates of the mean incubation time of COVID-19 by capitalizing on available estimates reported in the literature and exploring different ways to accommodate heterogeneity involved in the reported studies. The study finds that the reported estimates of the mean incubation time of COVID-19 vary considerably due to multiple reasons, including heterogeneity and publication bias. Our analyses show that the mean incubation time of COVID-19 between January 1, 2020 and May 20, 2021 ranges from 5.68 to 8.30 days.
Providing sensible estimates of the mean incubation time for COVID-19 is important yet complex. This study aims to provide synthetic estimates of the mean incubation time of COVID-19 by capitalizing on available estimates reported in the literature and exploring different ways to accommodate heterogeneity involved in the reported studies. Online databases between January 1, 2020 and May 20, 2021 are first searched to obtain estimates of the mean incubation time of COVID-19, and meta-analyses are then conducted to generate synthetic estimates. Heterogeneity of the studies is examined via the use of Cochran's Q $Q$ statistic and Higgin's & Thompson's I2 ${I}<^>{2}$ statistic, and subgroup analyses are conducted using mixed effects models. The publication bias issue is assessed using the funnel plot and Egger's test. Using all those reported mean incubation estimates for COVID-19, the synthetic mean incubation time is estimated to be 6.43 days with a 95% confidence interval (CI) [5.90, 6.96], and using all those reported mean incubation estimates together with those transformed median incubation estimates, the estimated mean incubation time is 6.07 days with a 95% CI [5.70, 6.45]. The reported estimates of the mean incubation time of COVID-19 vary considerably due to multiple reasons, including heterogeneity and publication bias. To alleviate these issues, we take different angles to provide a sensible estimate of the mean incubation time of COVID-19. Our analyses show that the mean incubation time of COVID-19 between January 1, 2020 and May 20, 2021 ranges from 5.68 to 8.30 days.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available