Equipoise, standard of care and consent: responding to the authorisation of new COVID-19 treatments in randomised controlled trials

Article Ethics

Value of choice

Tom Walker

Summary: Accounts of the value of patient choice often focus on the act of choosing, but this paper argues that the opportunity to choose is equally important. It suggests that having the chance to make decisions can reflect how one is seen as an equal and competent member of society, and this recognition has implications for healthcare professionals.

JOURNAL OF MEDICAL ETHICS (2022)

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Article Medicine, General & Internal

Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients

A. Jayk Bernal et al.

Summary: This study found that early treatment with molnupiravir reduced the risk of hospitalization or death in at-risk, unvaccinated adults with Covid-19.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Critical Care Medicine

Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Group Author Only

Summary: The study aimed to evaluate the efficacy and safety of colchicine in treating COVID-19 patients, but found that it did not reduce 28-day mortality, hospital stay duration, or risk of progressing to invasive mechanical ventilation or death.

LANCET RESPIRATORY MEDICINE (2021)

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Article Ethics

Back to WHAT? The role of research ethics in pandemic times

Jan Helge Solbakk et al.

Summary: The Covid-19 pandemic has brought about unprecedented challenges worldwide, necessitating critical reflection, new knowledge production, and immediate action despite knowledge gaps and uncertainty. Some advocate for exceptionalism in research ethics during this time, while others, including the authors of this paper, emphasize the importance of upholding core ethical principles and human rights obligations. This paper delves into the ongoing debate surrounding Covid-19 human challenge studies and the role of health-related research ethics during a pandemic, highlighting the need to learn from past harms and consider them in the current context.

MEDICINE HEALTH CARE AND PHILOSOPHY (2021)

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Article Immunology