Journal
CANCER CELL
Volume 28, Issue 4, Pages 405-406Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2015.09.016
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- NCI NIH HHS [F32 CA174148] Funding Source: Medline
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In a recent issue of Nature, Hsu and colleagues report that oncogenic MYC activation is synthetic lethal with inhibition of the core spliceosome, because MYC-driven growth and increased transcription leave tumors dependent on pre-mRNA processing for survival. As direct targeting of MYC has remained elusive, synthetic lethal strategies are attractive.
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