Journal
CANCER CELL
Volume 28, Issue 2, Pages 145-147Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2015.07.008
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Funding
- NIDDK NIH HHS [K99 DK103126] Funding Source: Medline
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In this issue of Cancer Cell, Herrero and colleagues identify an anti-tumorigenic small molecule that blocks ERK dimerization, but neither its catalytic activity nor its phosphorylation by MEK. These findings demonstrate that targeting protein dimerization could be a therapeutic avenue for inhibiting kinase signaling pathways associated with lower drug resistance.
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