Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 112, Issue 4, Pages 823-834Publisher
OXFORD UNIV PRESS
DOI: 10.1002/JLB.5MR0422-506R
Keywords
cytokine; IL-15; IL-2; immunotherapy; protein engineering
Categories
Funding
- National Key R&D Program of China [2019YFA0904400]
- Shenzhen Science and Technology Project [SGDX2020110309280301]
- Science and Technology Development Fund of Macau [FDCT/0004/2019/AFJ, FDCT/0043/2021/A1, FDCT/0002/2021/AKP]
- intramural research program of Faculty of Health Sciences, University of Macau [MYRG2019-00069FHS]
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This review outlines the potential and applications of IL-15 in cancer immunotherapy, discussing its role in regulating immune cells and providing prospects for future therapeutic designs.
Diverse cytokines and their receptors on immune cells constitute a highly complex network in the immune system. Some therapeutic cytokines and their derivatives have been approved for cancer treatment. IL-15 is an immune-regulating cytokine with multiple functions, among which the function of activating the immunity of cancer patients has great potential in cancer immunotherapy. In this review, we introduce the functions of IL-15 and discuss its role in regulating the immune system in different immune cells. Meanwhile, we will address the applications of IL-15 agonists in cancer immunotherapy and provide prospects for the next generation of therapeutic designs. Although many challenges remain, IL-15 agonists offer a new therapeutic option in the future direction of cancer immunotherapy.
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