4.3 Review

Mutations in the genome of severe acute respiratory syndrome coronavirus 2: implications for COVID-19 severity and progression

Related references

Note: Only part of the references are listed.
Article Virology

Omicron and Delta variant of SARS-CoV-2: A comparative computational study of spike protein

Suresh Kumar et al.

Summary: The emergence of the new SARS-CoV-2 variant, Omicron, has raised concerns due to its potential high affinity for human ACE2, indicating a higher transmission potential. Compared to the Delta variant, Omicron has a significantly different amino acid composition and protein structure, which may affect its stability and ACE2 binding.

JOURNAL OF MEDICAL VIROLOGY (2022)

Article Medicine, General & Internal

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study

Nicole Wolter et al.

Summary: According to data analysis from South Africa, individuals infected with the omicron variant have a lower likelihood of hospitalization compared to those infected with non-omicron variants. Furthermore, individuals infected with the omicron variant have a lower odds of severe disease compared to individuals infected with the earlier delta variant.

LANCET (2022)

Editorial Material Anesthesiology

Omicron SARS-CoV-2 variant: What we know and what we don't

Valentine Marie Ferre et al.

ANAESTHESIA CRITICAL CARE & PAIN MEDICINE (2022)

Article Public, Environmental & Occupational Health

COVID-19 Cases and Hospitalizations by COVID-19 Vaccination Status and Previous COVID-19 Diagnosis — California and New York, May–November 2021

Tomás M. León et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2022)

Article Biochemistry & Molecular Biology

Evidence of a SARS-CoV-2 double Spike mutation D614G/S939F potentially affecting immune response of infected subjects

Sara Donzelli et al.

Summary: The presence of undiscovered SARS-CoV-2 variants in Italy is described in this study. Deep sequencing analysis of respiratory samples revealed the D614G and S939F mutations. Unlike D614G, the S939F mutation has a slight but significant impact on immune response.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2022)

Article Infectious Diseases

Decreased severity of disease during the first global omicron variant covid-19 outbreak in a large hospital in tshwane, south africa

F. Abdullah et al.

Summary: This study analyzed the clinical data of COVID-19 patients admitted to a hospital in Tshwane during the Omicron wave, and found that the severity of the disease was decreased compared to previous waves, with lower death rates and ICU admissions.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

Article Biochemistry & Molecular Biology

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Erik Volz et al.

Summary: The study suggests a positive selection for the SARS-CoV-2 spike protein variant D614G in the UK, but no evidence of differences in COVID-19 mortality or clinical severity in patients infected with this variant. 614G is associated with higher viral load and younger age of patients compared to 614D.
Editorial Material Medicine, General & Internal

Genetic Variants of SARS-CoV-2-What Do They Mean?

Adam S. Lauring et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Public, Environmental & Occupational Health

Emergence of SARS-CoV-2 B.1.1.7 Lineage — United States, December 29, 2020–January 12, 2021

Summer E. Galloway et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

Article Infectious Diseases

Different mutations in SARS-CoV-2 associate with severe and mild outcome

Adam Nagy et al.

Summary: The study found a correlation between protein-level mutations in the SARS-CoV-2 virus and clinical outcomes, with some mutations associated with severe disease.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2021)

Letter Virology

Genomic Characterization of a Novel SARS-CoV-2 Lineage from Rio de Janeiro, Brazil

Carolina M. Voloch et al.

JOURNAL OF VIROLOGY (2021)

Article Multidisciplinary Sciences

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier et al.

Summary: The B.1.1.7 variant of SARS-CoV-2 exhibited reduced neutralization by vaccines and antibodies from recovered COVID-19 patients, with a more substantial loss seen when introducing the E484K mutation. This mutation poses a threat to the efficacy of the BNT162b2 vaccine.

NATURE (2021)

Article Biochemistry & Molecular Biology

Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera

Xuping Xie et al.

Summary: The study found that human sera from recipients of the BNT162b2 vaccine can neutralize SARS-CoV-2 viruses containing key spike mutations from the newly emerged UK and SA variants.

NATURE MEDICINE (2021)

Article Multidisciplinary Sciences

Genomic mutations and changes in protein secondary structure and solvent accessibility of SARS-CoV-2 (COVID-19 virus)

Thanh Thi Nguyen et al.

Summary: This study analyzed genomic mutations in the coding regions of SARS-CoV-2 and their impact on protein secondary structure and solvent accessibility, indicating the establishment of a mutation dataset beneficial for virus tracking, as well as identifying stable coding genes suitable for vaccine and drug development.

SCIENTIFIC REPORTS (2021)

Review Medicine, Research & Experimental

Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines

Wagner Gouvea Dos Santos

Summary: Despite global efforts, there are still many challenges and unanswered questions in the search for an effective way to prevent the spread of COVID-19. Scientists are currently debating issues such as reinfection of recovered individuals, duration of immunity, and the potential impact of mutations on the efficacy of vaccines. Ongoing clinical trials for various vaccines remain hopeful, but definitive conclusions on safety and efficacy will require further time and research.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies

Markus Hoffmann et al.

Summary: The emerging SARS-CoV-2 variants may exhibit resistance to existing neutralizing antibodies and treatments, which could have significant implications for pandemic containment efforts.
Article Public, Environmental & Occupational Health

The Disease Severity and Clinical Outcomes of the SARS-CoV-2 Variants of Concern

Lixin Lin et al.

Summary: Studies have shown that Alpha, Beta, Gamma, and Delta variants of SARS-CoV-2 have increased severity in terms of hospitalization, ICU admission, and mortality compared to the wild-type virus, with Beta and Delta variants posing higher risks.

FRONTIERS IN PUBLIC HEALTH (2021)

Article Endocrinology & Metabolism

Elucidating reasons of COVID-19 re-infection and its management strategies

Vijay Kumar Jain et al.

Summary: This study found that the main reasons for COVID-19 reinfection may include the emergence of variant viruses, pandemic fatigue, and disregard for infection prevention strategies. Therefore, it is necessary to take COVID Appropriate Behavior, promote vaccine improvement, and enhance global vaccination efforts to mitigate this global threat.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

Article Multidisciplinary Sciences

Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans

Bas B. Oude Munnink et al.

Summary: Animal experiments have shown that various animals can be infected by SARS-CoV-2, with evidence of animal-to-human transmission within mink farms. Investigation into mink farm outbreaks revealed that the virus was initially introduced by humans and has since evolved, causing transmission between mink farms. Despite enhanced biosecurity measures and culling, transmission occurred between farms in three large clusters with unknown modes of transmission, resulting in a high percentage of infections among mink farm residents and employees.

SCIENCE (2021)

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

Editorial Material Microbiology

The importance of naturally attenuated SARS-CoV-2in the fight against COVID-19

Jean Armengaud et al.

ENVIRONMENTAL MICROBIOLOGY (2020)

Article Biotechnology & Applied Microbiology

Understanding SARS-CoV-2: Genetic Diversity, Transmission and Cure in Human

Abhay Bajaj et al.

INDIAN JOURNAL OF MICROBIOLOGY (2020)

Article Medicine, General & Internal

SARS-CoV-2 viral spike G614 mutation exhibits higher case fatality rate

Manuel Becerra-Flores et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2020)

Article Multidisciplinary Sciences

On the origin and continuing evolution of SARS-CoV-2

Xiaolu Tang et al.

NATIONAL SCIENCE REVIEW (2020)

Article Virology

Phylogenetic analysis of the first four SARS-CoV-2 cases in Chile

Andres E. Castillo et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Article Virology

Genetic variants and source of introduction of SARS-CoV-2 in South America

Julio A. Poterico et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Article Medicine, Research & Experimental

Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

Maria Pachetti et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Article Multidisciplinary Sciences

Virological assessment of hospitalized patients with COVID-2019

Roman Woelfel et al.

NATURE (2020)

Letter Biochemistry & Molecular Biology

The proximal origin of SARS-CoV-2

Kristian G. Andersen et al.

NATURE MEDICINE (2020)

Article Public, Environmental & Occupational Health

Variant analysis of SARS-CoV-2 genomes

Takahiko Koyama et al.

BULLETIN OF THE WORLD HEALTH ORGANIZATION (2020)

Article Biochemistry & Molecular Biology

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

Qianqian Li et al.

Article Infectious Diseases

Genetic diversity and evolution of SARS-CoV-2

Tung Phan

INFECTION GENETICS AND EVOLUTION (2020)

Article Pathology

In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19

Inga-Marie Schaefer et al.

MODERN PATHOLOGY (2020)

Review Biochemistry & Molecular Biology

Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting

Fran Robson et al.

MOLECULAR CELL (2020)

Article Infectious Diseases

Emerging genetic diversity among clinical isolates of SARS-CoV-2: Lessons for today

Javaid Ahmad Sheikh et al.

INFECTION GENETICS AND EVOLUTION (2020)

Review Infectious Diseases

A systematic review and meta-analysis of published research data on COVID-19 infection fatality rates

Gideon Meyerowitz-Katz et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Article Multidisciplinary Sciences

Genome-wide analysis of SARS-CoV-2 virus strains circulating worldwide implicates heterogeneity

M. Rafiul Islam et al.

SCIENTIFIC REPORTS (2020)

Review Public, Environmental & Occupational Health

Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications

Andrew T. Levin et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2020)

Article Multidisciplinary Sciences

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

Yixuan J. Hou et al.

SCIENCE (2020)

Article Genetics & Heredity

Genomic characterization of a novel SARS-CoV-2

Rozhgar A. Khailany et al.

GENE REPORTS (2020)

Article Biochemistry & Molecular Biology

Why are RNA virus mutation rates so damn high?

Siobain Duffy

PLOS BIOLOGY (2018)

Editorial Material Infectious Diseases

GISAID: Global initiative on sharing all influenza data - from vision to reality

Yuelong Shu et al.

EUROSURVEILLANCE (2017)

Review Biochemistry & Molecular Biology

Mechanisms of viral mutation

Rafael Sanjuan et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Article Multidisciplinary Sciences

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Lorenzo Subissi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Editorial Material Biochemistry & Molecular Biology

Does mutation rate depend on itself?

Charles F. Baer

PLOS BIOLOGY (2008)