Journal
JOURNAL OF INTERNAL MEDICINE
Volume 292, Issue 3, Pages 450-462Publisher
WILEY
DOI: 10.1111/joim.13493
Keywords
administrative database; clinical sequalae; Lombardy region; long-COVID; polypharmacy; population study; SARS-CoV-2
Categories
Funding
- Regione Lombardia [3375-14]
- Health Ministry of Lombardy
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This study analyzed data from COVID-19 survivors in Lombardy to reveal the increased rates of rehospitalization, emergency room visits, and outpatient visits in the 6 months following recovery. Various medical tests and drug usage also significantly increased, indicating an increased burden on healthcare resources in the post-COVID-19 condition.
Background Lombardy was affected in the early months of 2020 by the SARS-CoV-2 pandemic with very high morbidity and mortality. The post-COVID-19 condition and related public health burden are scarcely known. Setting and design Using the regional population administrative database including all the 48,932 individuals who survived COVID-19 and became polymerase-chain-reaction negative for SARS-CoV-2 by 31 May 2020, incident mortality, rehospitalizations, attendances to hospital emergency room, and outpatient medical visits were evaluated over a mid-term period of 6 months in 20,521 individuals managed at home, 26,016 hospitalized in medical wards, and 1611 in intensive care units (ICUs). These data were also evaluated in the corresponding period of 2019, when the region was not yet affected by the pandemic. Other indicators and proxies of the health-care burden related to the post-COVID condition were also evaluated. Main results In individuals previously admitted to the ICU and medical wards, rehospitalizations, attendances to hospital emergency rooms, and out-patient medical visits were much more frequent in the 6-month period after SARS-CoV-2 negativization than in the same prepandemic period. Performances of spirometry increased more than 50-fold, chest CT scans 32-fold in ICU-admitted cases and 5.5-fold in non-ICU cases, and electrocardiography 5.6-fold in ICU cases and twofold in non-ICU cases. Use of drugs and biochemical tests increased in all cases. Conclusions These results provide a real-life picture of the post-COVID condition and of its effects on the increased consumption of health-care resources, considered proxies of comorbidities.
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