☆ 4.7 Article

Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations

JOURNAL OF INTERNAL MEDICINE (2022)

Related references

Note: Only part of the references are listed.

Article Medicine, General & Internal

Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement

H. Hoel et al.

Summary: Patients with cardiac involvement in COVID-19 showed elevated markers of gut leakage and inflammasome activation, suggesting a potential gut-heart axis in the disease. Levels of LBP were significantly higher in patients with elevated cardiac markers compared to those without, and remained elevated during hospitalization. Additionally, markers of inflammasome activation were moderately elevated in patients with cardiac involvement.

JOURNAL OF INTERNAL MEDICINE (2021)

Add to Collection

Article Respiratory System

Dyspnoea, lung function and CT findings 3 months after hospital admission for COVID-19

Tori Vigeland Lerum et al.

Summary: The long-term pulmonary outcomes of COVID-19 after 3 months of hospital admission include chest CT opacities and reduced diffusing capacity in one-fourth of the participants. ICU patients did not show significant differences in dyspnoea scores and lung function, but had a higher prevalence of abnormal chest CT findings.

EUROPEAN RESPIRATORY JOURNAL (2021)

Add to Collection

Article Respiratory System

Pulmonary function and radiological features 4 months after COVID-19: first results from the national prospective observational Swiss COVID-19 lung study

Sabina A. Guler et al.

Summary: The Swiss COVID-19 lung study investigated pulmonary sequelae of COVID-19 in 113 survivors. Severe/critical COVID-19 was associated with significant functional and radiological abnormalities 4 months after infection, potentially due to small-airway and lung parenchymal disease. Systematic follow-up for survivors needs to be evaluated to optimize care for patients recovering from COVID-19.

EUROPEAN RESPIRATORY JOURNAL (2021)

Add to Collection

Article Gastroenterology & Hepatology

Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

Yun Kit Yeoh et al.

Summary: This study found that the gut microbiome composition was significantly altered in patients with COVID-19 compared to non-COVID-19 individuals, regardless of medication received. Certain gut commensals known for their immunomodulatory potential were underrepresented in patients and remained low even after disease resolution. Additionally, the altered gut microbiome composition correlated with disease severity and elevated levels of inflammatory cytokines and blood markers.

GUT (2021)

Add to Collection

Article Medicine, General & Internal

Repurposed Antiviral Drugs for Covid-19-Interim WHO Solidarity Trial Results

Summary: The authors of the study reported the interim results of using four repurposed antiviral drugs (remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a) in hospitalized COVID-19 patients. The study showed that these drug regimens had little or no effect on overall mortality, initiation of ventilation, and duration of hospital stay.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection

Editorial Material Immunology

Could Perturbation of Gut Microbiota Possibly Exacerbate the Severity of COVID-19 via Cytokine Storm?

Ramachandran Vignesh et al.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Immunology

Microbiota Modulation of the Gut-Lung Axis in COVID-19

Gislane Lelis Vilela de Oliveira et al.

Summary: COVID-19, caused by SARS-CoV-2, affects respiratory and gastrointestinal systems, with prolonged gastrointestinal manifestations possibly linked to alterations in gut microbiota and immune responses; the bidirectional interactions between respiratory mucosa and gut microbiota may play a crucial role in immune responses to the virus.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Impact of Altered Gut Microbiota and Its Metabolites in Cystic Fibrosis

Aravind Thavamani et al.

Summary: Cystic fibrosis is a deadly genetic disorder that affects fluid regulation and pH balance in the body, as well as gut dysbiosis. Due to the use of antibiotics and inherent dysfunction of CFTR, gut dysbiosis can have an impact on various symptoms of cystic fibrosis.

METABOLITES (2021)

Add to Collection

Article Multidisciplinary Sciences

Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9

Tori Vigeland Lerum et al.

Summary: The study investigated the association between pulmonary sequelae and markers of disease severity in 108 patients 3 months after hospital admission for COVID-19. Factors such as low pO(2)/FiO2 ratio, ICU treatment, high viral load, low antibody levels, and high levels of matrix metalloproteinase-9 (MMP-9) were found to be associated with worse pulmonary outcomes. High prevalence of respiratory symptoms, reduced diffusion capacity of the lungs (DLCO), and persistent CT findings were observed 3 months after hospital admission.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Medicine, General & Internal

Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 A Randomized Trial

Andreas Barratt-Due et al.

Summary: A randomized controlled trial conducted in 23 hospitals in Norway found that remdesivir and hydroxychloroquine did not affect viral clearance in hospitalized COVID-19 patients. There was also no impact on mortality, degree of respiratory failure, or inflammatory variables.

ANNALS OF INTERNAL MEDICINE (2021)

Add to Collection

Article Medicine, Research & Experimental

Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier

Lael M. Yonker et al.

Summary: In children with MIS-C, prolonged presence of SARS-CoV-2 in the GI tract led to the release of zonulin, a biomarker of intestinal permeability, and subsequent trafficking of SARS-CoV-2 antigens into the bloodstream, resulting in hyperinflammation. Treatment with larazotide, a zonulin antagonist, reduced plasma SARS-CoV-2 spike antigen levels and inflammatory markers in a patient with MIS-C, leading to clinical improvement beyond current available treatments. These mechanistic insights provide potential targets for diagnosing, treating, and preventing MIS-C in children.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Article Immunology

Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients

Leila B. Giron et al.

Summary: The disruption of crosstalk between the gut and lung is implicated as a driver of severity in respiratory-related diseases. Severe COVID-19 is associated with high levels of markers indicating disrupted gut permeability, microbial translocation, and systemic inflammation, which correlate strongly with other disruptions in the body and higher mortality rates. It highlights the importance of gut functions in contributing to the severity of COVID-19.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Immunology

Impact of Human Immunodeficiency Virus-Related Gut Microbiota Alterations on Metabolic Comorbid Conditions

Marco Gelpi et al.

CLINICAL INFECTIOUS DISEASES (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Low fibre intake is associated with gut microbiota alterations in chronic heart failure

Cristiane C. K. Mayerhofer et al.

ESC HEART FAILURE (2020)

Add to Collection

Article Gastroenterology & Hepatology

Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization

Tao Zuo et al.

GASTROENTEROLOGY (2020)

Add to Collection

Article Immunology

Alterations of the Gut Microbiota in Patients With Coronavirus Disease 2019 or H1N1 Influenza

Silan Gu et al.

CLINICAL INFECTIOUS DISEASES (2020)

Add to Collection

Review Pathology

Pathologic features of COVID-19: A concise review

Mohammadreza Tabary et al.

PATHOLOGY RESEARCH AND PRACTICE (2020)

Add to Collection

Review Gastroenterology & Hepatology

COVID-19 pandemic: Pathophysiology and manifestations from the gastrointestinal tract

Michail Galanopoulos et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2020)

Add to Collection

Review Microbiology

Gut Microbiota Dysbiosis-Immune Hyperresponse-Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches

Carolina Ferreira et al.

MICROORGANISMS (2020)

Add to Collection

Article Medicine, General & Internal

Intestinal Inflammation in Children with Cystic Fibrosis Is Associated with Crohn's-Like Microbiota Disturbances

Raphael Enaud et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Add to Collection

Article Critical Care Medicine

Standardization of Spirometry 2019 Update An Official American Thoracic Society and European Respiratory Society Technical Statement

Brian L. Graham et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Add to Collection

Article Gastroenterology & Hepatology

The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls

Martin Kummen et al.

GUT (2017)

Add to Collection

Article Respiratory System

Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians

Sanja Stanojevic et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

Add to Collection

Article Respiratory System

2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung

Brian L. Graham et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

Add to Collection

Article Immunology

Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation

S. F. Jorgensen et al.

MUCOSAL IMMUNOLOGY (2016)

Add to Collection

Article Immunology

Gut microbiota diversity predicts immune status in HIV-1 infection

Piotr Nowak et al.

AIDS (2015)

Add to Collection

Article Critical Care Medicine

The Role of Bacteria in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis

Phillip L. Molyneaux et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

Add to Collection

Article Microbiology

An improved dual-indexing approach for multiplexed 16S rRNA gene sequencing on the Illumina MiSeq platform

Douglas W. Fadrosh et al.

MICROBIOME (2014)

Add to Collection

Review Immunology

The role of lipopolysaccharide-binding protein in modulating the innate immune response

Janine Zweigner et al.

MICROBES AND INFECTION (2006)

Add to Collection

© Peeref 2019-2024. All rights reserved.