Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 226, Issue 7, Pages 1184-1194Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiac147
Keywords
circumcision; male circumcision; HPV; human papillomavirus; sexually transmitted infections
Categories
Funding
- Canadian Institutes of Health Research [MOP-68893, CRN-83320]
- United States National Institutes of Health [RO1AI073889]
- Merck-Frosst Canada Ltd
- Merck Co Ltd.
- Reseau sida et maladies infectieuses du Fonds de recherche du Quebec-Sante
- Carole Epstein Fellowship - McGill University
- Canadian Institutes of Health Research
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In this longitudinal study, there was no strong evidence for a relationship between male circumcision and the prevalence, transmission, or clearance of human papillomavirus infections in males and females.
In this longitudinal study of 413 heterosexual monogamous couples, there was no strong evidence of a relationship between male circumcision and the prevalence, transmission, or clearance of human papillomavirus infections in males and females. Background Previous studies examining the association between male circumcision (MC) and human papillomavirus (HPV) infections have reported inconsistent results. We used data from the HPV Infection and Transmission Among Couples Through Heterosexual Activity (HITCH) cohort study to examine the association between MC and HPV infections in males and their female sexual partners. Methods We enrolled monogamous couples in a longitudinal study between 2005 and 2011 in Montreal, Canada. We used logistic and Poisson regression models with propensity score adjustment to estimate odds ratios (ORs) and rate ratios for the association between MC and the prevalence, transmission, and clearance of HPV infections. Results Four hundred thirteen couples were included in our study. The prevalence OR for the association between MC and baseline infections was 0.81 (95% confidence interval [CI], .56-1.16) in males and 1.05 (95% CI, .75-1.46) in females. The incidence rate ratio for infection transmission was 0.59 (95% CI, .16-2.20) for male-to-female transmission and 0.77 (95% CI, .37-1.60) for female-to-male transmission. The clearance rate ratio for clearance of infections was 0.81 (95% CI, .52-1.24). Conclusions We found little evidence of an association between MC and HPV infection prevalence, transmission, or clearance in males and females. Further longitudinal couple-based studies are required to investigate this association.
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