Microwave-assisted one-pot multicomponent synthesis of 2-(-4-oxo-2-(1-(2-oxo-2h-chromen-3-yl) ethylidene)hydrazono)thiazolidin-5-yl) acetic acid derivatives and their antiviral activity

A novel series of hydrazonothiazolidinyl acetic acid derivatives were synthesized via a straightforward microwave irradiated one-pot multicomponent reaction approach using substituted 3-acetylcoumarins (1a-l), thiosemicarbazide (2), and maleic anhydride (3). The synthesis was carried out by using sodium acetate and acetic acid as a solvent at 70 degrees C, afforded target molecules in a shorter reaction time, simple reaction workup with high yields. All the synthesized compounds were well characterized by analytical data (H-1, C-13 NMR and mass spectra). In vitro antiviral activity of thiazolidinyl acetic acid derivatives were evaluated against a broad panel of human viruses in different cell lines among which compound 4d exhibited excellent activity against Herpes simplex virus-1.

Automated summary

A novel series of hydrazonothiazolidinyl acetic acid derivatives were synthesized via a straightforward microwave irradiated one-pot multicomponent reaction approach. The synthesized compounds exhibited good characterization and antiviral activity, particularly against Herpes simplex virus-1.