Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 426, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2021.128042
Keywords
Bisphenol S; Zebrafish; Macrophage; Lipid metabolism; Atherosclerosis
Categories
Funding
- National Natural Science Foundation of China [31971235]
Ask authors/readers for more resources
BPS exposure accelerates the progression of ASCVD, inducing characteristic symptoms in zebrafish embryo-larvae model, such as inflammation, macrophage recruitment, and oxLDL accumulation in blood vessels.
Bisphenol S (BPS), widely utilized in manufacturing of daily necessities, is a toxicant with potential to induce atherosclerotic cardiovascular disease (ASCVD). However, the mode of action by which BPS exposure induces ASCVD remains unknown. Here, macrophages that were exposed to BPS in combination with oxidized lowdensity lipoprotein (oxLDL) exhibited enhanced formation of foam cells, a hallmark of ASCVD. Furthermore, zebrafish embryo-larvae were exposed to BPS (0, 1, 10 and 100 mu g/L) for 15 days (d) and the characteristic symptoms of ASCVD including an inflammatory response, macrophage recruitment around blood vessels, and accumulation of oxLDL on vascular endothelium, were induced in 15-d larvae. After zebrafish were exposed to BPS for 45 d, BPS mobilized fatty acid metabolism and activated peroxisome proliferator-activated receptor signaling in larval liver, the hub of endogenous lipid metabolism, causing an increase in plasma LDL. Driven by high plasma LDL levels, the caudal artery of zebrafish larvae exhibited lipid accumulation and a thickened area with a large number of collagen fibers, accompanied by characteristic lesions, as well as hyperlipidemia, erythrocyte aggregation, thinner blood vessel walls and increased levels of leukocytes and thromboocytes in plasma. Our data demonstrate that BPS accelerates the progression of ASCVD using zebrafish embryo-larvae as a model.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available