4.7 Article

Paper The multiple biotoxicity integrated study in grass carp (Ctenopharyngodon idella) caused by Ochratoxin A: Oxidative damage, apoptosis and immunosuppression

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Quercetin ameliorates ochratoxin A-Induced immunotoxicity in broiler chickens by modulation of PI3K/AKT pathway

Rehab E. Abdelrahman et al.

Summary: The study showed that OTA exposure in broiler chickens resulted in suppressed immune responses, oxidative stress, and apoptotic effects in various organs, while QUE administration alleviated these immunotoxic effects by modulating the immune system, reducing oxidative stress, and inhibiting apoptosis.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

Article Toxicology

Ameliorative role of dietary activated carbon against ochratoxin-A induced oxidative damage, suppressed performance and toxicological effects

Sheraz Ahmed Bhatti et al.

Summary: The present study found that adding activated charcoal can partially reduce the toxic effects caused by ochratoxin A in broiler feed, particularly at lower doses. However, at higher doses, activated charcoal is ineffective and may have toxicological effects on broiler chickens.

TOXIN REVIEWS (2022)

Article Biochemistry & Molecular Biology

Hormesis: Transforming disciplines that rely on the dose response

Edward J. Calabrese et al.

Summary: Hormesis is a fundamental evolutionary adaptive strategy that can decelerate common age-related health problems. Incorporating hormetic-based lifestyle options within the population would have profound positive impacts on public health.

IUBMB LIFE (2022)

Article Pharmacology & Pharmacy

Ochratoxin A: Occurrence and recent advances in detoxification

Lan Wang et al.

Summary: This paper reviews the source, occurrence, and latest achievements in the removal and detoxification of Ochratoxin A (OTA) in food and agricultural products. The influencing factors and mechanisms related to the biodetoxification of OTA are discussed, as well as the advantages, disadvantages, and potential application prospects of these methods.

TOXICON (2022)

Article Oncology

Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy

Kristin G. Anderson et al.

Summary: Combining Fas/FasL signaling with immunotherapy can enhance the efficacy of ovarian cancer T cells and prolong survival in mouse models.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

Article Environmental Sciences

Lead impaired immune function and tissue integrity in yellow catfish (Peltobargus fulvidraco) by mediating oxidative stress, inflammatory response and apoptosis

Jie Guo et al.

Summary: The study investigated the toxic effects of waterborne lead exposure on immune organs of yellow catfish, showing that lead exposure led to bioaccumulation, histomorphological alterations, changes in antioxidant status, apoptotic processes, and immune responses. The results suggest that lead exposure can impair immune function and tissue integrity in yellow catfish through oxidative stress, inflammation, and apoptosis.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Environmental Sciences

Zearalenone induces immuno-compromised status via TOR/NF/κB pathway and aggravates the spread of Aeromonas hydrophila to grass carp gut (Ctenopharyngodon idella)

Hong-Yun Zhang et al.

Summary: The study discussed the effects of zearalenone on intestinal immune components, cytokines and molecular mechanisms of juvenile grass carp, pointing out that zearalenone inhibits immune components in the intestines and may increase the risk of mucosal exposure and associated diseases.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Review Pharmacology & Pharmacy

Neuroprotection through G-CSF: recent advances and future viewpoints

Vikrant Rahi et al.

Summary: G-CSF is a cytokine that plays a crucial role in the proliferation and survival of neutrophilic granulocytes, and recent studies have shown its neuroprotective effects including promoting neuronal survival, proliferation, and differentiation.

PHARMACOLOGICAL REPORTS (2021)

Article Pharmacology & Pharmacy

Follow up long term preliminary studies on carcinogenic and toxic effects of ochratoxin A in rats and the putative protection of phenylalanine

Stoycho D. Stoev

Summary: Wistar rats exposed to OTA showed degenerative changes in internal organs, with PHE supplementation demonstrating a protective effect on serum glucose and protein levels. However, the protective effect on serum enzyme activity was not significant. PHE supplementation group exposed to 10 ppm OTA showed similar tumor numbers to the group exposed to lower levels of OTA, suggesting a potential protective effect of PHE.

TOXICON (2021)

Article Food Science & Technology

Effects of Dietary Ochratoxin A on Growth Performance and Intestinal Apical Junctional Complex of Juvenile Grass Carp (Ctenopharyngodon idella)

Xin Liu et al.

Summary: The study confirmed that OTA has negative effects on fish growth and intestinal structure, causing decreased weight gain, accumulation in the intestine, oxidative damage, increased intestinal permeability, and induction of the RhoA/ROCK signaling pathway, leading to disruption of the intestinal apical junctional complexes.

TOXINS (2021)

Article Environmental Sciences

Assessment of DNA damage induced by endosulfan in grass carp (Ctenopharyngodon idella Valenciennes, 1844)

Muhammad Khisroon et al.

Summary: The study evaluated the genotoxic effect of endosulfan on grass carp blood, finding that exposure to this pesticide led to significant DNA damage in a time- and dose-dependent manner. As endosulfan demonstrated severe genotoxic effects on Ctenopharyngodon idella, the study recommends that its use be controlled and monitored by government authorities to prevent further harm to ecosystems.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

Article Engineering, Environmental

Nanopolystyrene particles at environmentally relevant concentrations causes behavioral and biochemical changes in juvenile grass carp (Ctenopharyngodon idella)

Abraao Tiago Batista Guimara et al.

Summary: The exposure of grass carp juveniles to different concentrations of PS NPs did not lead to increased biometric parameters, but affected their individual and collective behavior, as well as biochemical parameters. Despite no damage to locomotor and visual abilities, PS NPs influenced locomotor activity in response to vibratory stimuli and anti-predatory behavior in the presence of a potential predator, indicating potential health effects on early-life stage grass carp individuals.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Environmental Sciences

Effects of 4-epianhydrotetracycline on oxidative stress in zebrafish (Danio rerio) embryos

Meng Wang et al.

Summary: 4-EATC, a major intermediate product during tetracycline degradation, was studied for ecotoxicity in zebrafish embryos. Low concentrations did not significantly affect oxidative stress, while high concentrations led to oxidative damage and increased apoptosis rates in embryonic cells.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Food Science & Technology

Grape Seed Proanthocyanidin Ameliorates FB1-Induced Meiotic Defects in Porcine Oocytes

Wenhui Li et al.

Summary: The study demonstrated that 200 μM GSP cotreatment effectively alleviated the toxic effects of FB1 exposure, promoting first polar body extrusion and improving subsequent cleavage and blastocyst development rates.

TOXINS (2021)

Article Biochemistry & Molecular Biology

Effects of acute iron overload on Nrf2-related glutathione metabolism in rat brain

Natacha E. Piloni et al.

Summary: Acute iron overload in rat brain induces oxidative stress, depletion of glutathione, and increased lipid peroxidation, which leads to the upregulation of Nrf2-mediated antioxidant regulation. This protective adaptive response is characterized by the elevation of GPx, GPx-Se, and GST protein expression. Further studies are needed to fully understand the intricate network of processes involved in maintaining GSH functions and the mechanisms triggered by iron overload in the brain.

BIOMETALS (2021)

Article Cell Biology

Neutralization of IL-17 and treatment with IL-2 protects septic arthritis by regulating free radical production and antioxidant enzymes in Th17 and Tregs: An immunomodulatory TLR2 versus TNFR response

Rituparna Ghosh et al.

Summary: Septic arthritis caused by Staphylococcus aureus involves Th17 proliferation and down regulation of Treg cells, indicating that targeting IL-17 may be important for controlling inflammation. The study also found that neutralization of IL-17 or IL-2 treatment can regulate septic arthritis by enhancing the anti-inflammatory properties of Treg cells via antioxidant balance and modulating TLR2/TNFR response.

CELLULAR IMMUNOLOGY (2021)

Article Engineering, Environmental

Cu-induced spermatogenesis disease is related to oxidative stress-mediated germ cell apoptosis and DNA damage

Hongrui Guo et al.

Summary: Copper is essential but over-exposure can lead to adverse health effects. CuSO4 was found to induce spermatogenesis disorder through oxidative stress-mediated DNA damage and apoptosis, impairing male reproductive function.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Pharmacology & Pharmacy

The effect of ochratoxin A on cytotoxicity and glucose metabolism in human esophageal epithelium Het-1A cells

Man Zhao et al.

Summary: OTA induces apoptosis, oxidative damage, mitochondrial dysfunction, and perturbs glucose metabolism in esophageal epithelial cells, potentially playing pivotal roles in the mechanism of OTA-induced esophageal toxicity.

TOXICON (2021)

Article Nanoscience & Nanotechnology

Synthesis, characterization and protective effect of green tea-mediated zinc oxide nanoparticles against ochratoxin A induced hepatotoxicity and nephrotoxicity in albino rats

Syeda Aamna Hassan et al.

Summary: This study demonstrates the synthesis, characterization, and hepatoprotective and nephroprotective effects of green tea mediated zinc oxide nanoparticles against OTA-induced hepatotoxicity and nephrotoxicity in albino rats. The ZnONPs showed a significant reduction in the negative effects caused by OTA, including improvements in body weight gain, liver and kidney tissue pathology. The findings suggest that ZnONPs synthesized using green tea may have potential therapeutic applications in protecting against OTA-related health issues in rats.

APPLIED NANOSCIENCE (2021)

Article Environmental Sciences

Melatonin ameliorates ochratoxin A-induced oxidative stress and apoptosis in porcine oocytes

Mei Lan et al.

ENVIRONMENTAL POLLUTION (2020)

Review Environmental Sciences

Ochratoxin A-induced genotoxic and epigenetic mechanisms lead to Alzheimer disease: its modulation with strategies

Kamal Niaz et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020)

Article Chemistry, Applied

Occurrence and bioacessibility of mycotoxins in fish feed

Wesclen Vilar Nogueira et al.

FOOD ADDITIVES & CONTAMINANTS PART B-SURVEILLANCE (2020)

Article Biochemistry & Molecular Biology

TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data

Chengjie Chen et al.

MOLECULAR PLANT (2020)

Article Food Science & Technology

Effects of Subcutaneous Ochratoxin-A Exposure on Immune System of Broiler Chicks

Shahzad Akbar Khan et al.

TOXINS (2019)

Article Chemistry, Applied

A risk assessment of dietary exposure to ochratoxin A for the Polish population

Ilona Hajok et al.

FOOD CHEMISTRY (2019)

Article Environmental Sciences

Insights into the heavy metal-induced immunotoxic and genotoxic alterations as health indicators of Clarias gariepinus inhabiting a rivulet

Umarah Zahoor Banday et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2019)

Article Medicine, General & Internal

Glucose fluctuation increased mesangial cell apoptosis related to AKT signal pathway

Changjiang Ying et al.

ARCHIVES OF MEDICAL SCIENCE (2019)

Article Biochemistry & Molecular Biology

Activation of AMPK-dependent SIRT-1 by astragalus polysaccharide protects against ochratoxin A-induced immune stress in vitro and in vivo

Dandan Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Article Food Science & Technology

Ochratoxin A induces cytoprotective autophagy via blocking AKT/mTOR signaling pathway in PK-15 cells

Gang Qian et al.

FOOD AND CHEMICAL TOXICOLOGY (2018)

Article Toxicology

Protective role of bentonite against aflatoxin B1- and ochratoxin A-induced immunotoxicity in broilers

Sheraz Ahmed Bhatti et al.

JOURNAL OF IMMUNOTOXICOLOGY (2017)

Article Fisheries

Nocardia seriolae infection in cultured jade perch, Scortum barcoo

Fang Wang et al.

AQUACULTURE INTERNATIONAL (2017)

Article Agriculture, Dairy & Animal Science

Toxic Effects of Ochratoxin A on Calcium Metabolism during Chick Embryo Developmentand in Hatched Chicks

M. A. E. Elsayed et al.

BRAZILIAN JOURNAL OF POULTRY SCIENCE (2017)

Article Public, Environmental & Occupational Health

Lycopene restores trace element levels in ochratoxin A-treated rats

Saziye Sezin Palabiyik et al.

ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY (2017)

Article Marine & Freshwater Biology

Developmental and acute toxicity of cetylpyridinium chloride in Bombina orientalis (Amphibia: Anura)

Chan Jin Park et al.

AQUATIC TOXICOLOGY (2016)

Article Pathology

Immunohistochemistry of apoptosis-related proteins in retinoblastoma

Renato Jose Mendonca Natalino et al.

PATHOLOGY RESEARCH AND PRACTICE (2016)

Article Medicine, Research & Experimental

Podophyllotoxin acetate enhances gamma-ionizing radiation-induced apoptotic cell death by stimulating the ROS/p38/caspase pathway

Jae Yeon Choi et al.

BIOMEDICINE & PHARMACOTHERAPY (2015)

Article Nanoscience & Nanotechnology

TiO2 nanoparticles induce oxidative DNA damage and apoptosis in human liver cells

Ritesh K. Shukla et al.

NANOTOXICOLOGY (2013)

Article Pharmacology & Pharmacy

Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish

Lu Wang et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)

Meeting Abstract Toxicology

Comparison of the accumulation of ochratoxin A residues in treated pig tissues

Jelka Pleadin et al.

TOXICOLOGY LETTERS (2013)

Article Ophthalmology

Transcription Factor Nrf2-Mediated Antioxidant Defense System in the Development of Diabetic Retinopathy

Qing Zhong et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)

Review Allergy

Oxidative Stress and Antioxidant Defense

Esra Birben et al.

WORLD ALLERGY ORGANIZATION JOURNAL (2012)

Article Marine & Freshwater Biology

Accumulation of dietary and aqueous cadmium into the epidermal mucus of the discus fish Symphysodon sp.

Richard J. Maunder et al.

AQUATIC TOXICOLOGY (2011)

Article Biochemistry & Molecular Biology

The Holo-Apoptosome: Activation of Procaspase-9 and Interactions with Caspase-3

Shujun Yuan et al.

STRUCTURE (2011)

Review Veterinary Sciences

Innate and adaptive immunity in teleost fish: a review

C. Uribe et al.

VETERINARNI MEDICINA (2011)

Review Biochemistry & Molecular Biology

Non-caspase proteases: triggers or amplifiers of apoptosis?

Karen Schrader et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2010)

Article Immunology

TCR-Dependent Translational Control of GATA-3 Enhances Th2 Differentiation

Kevin D. Cook et al.

JOURNAL OF IMMUNOLOGY (2010)

Review Nutrition & Dietetics

Inflammatory Disease Processes and Interactions with Nutrition

P. C. Calder et al.

BRITISH JOURNAL OF NUTRITION (2009)

Review Pharmacology & Pharmacy

Targeting JAK/STAT Signaling Pathway in Inflammatory Diseases

Charles Jay Malemud et al.

CURRENT SIGNAL TRANSDUCTION THERAPY (2009)

Article Genetics & Heredity

Comprehensive clarification of two paralogous interleukin 4/13 loci in teleost fish

Maki Ohtani et al.

IMMUNOGENETICS (2008)

Review Pharmacology & Pharmacy

Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms

Maricel Marin-Kuan et al.

TOXICON (2008)

Article Biochemistry & Molecular Biology

The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply

Peter R. Hoffmann et al.

NUCLEIC ACIDS RESEARCH (2007)

Review Pharmacology & Pharmacy

Mitochondrial oxidative stress: Implications for cell death

Sten Orrenius et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2007)

Article Pharmacology & Pharmacy

Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response

Peter J. Murray

CURRENT OPINION IN PHARMACOLOGY (2006)

Review Fisheries

Melano-macrophage centres and their role in fish pathology

C Agius et al.

JOURNAL OF FISH DISEASES (2003)

Article Biochemistry & Molecular Biology

Nitric oxide stimulates Nrf2 nuclear translocation in vascular endothelium

BJ Buckley et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

Review Biochemistry & Molecular Biology

Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells

H Imai et al.

FREE RADICAL BIOLOGY AND MEDICINE (2003)

Article Dentistry, Oral Surgery & Medicine

Intracellular calcium in signaling human beta-defensin-2 expression in oral epithelial cells

S Krisanaprakornkit et al.

JOURNAL OF DENTAL RESEARCH (2003)