Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 432, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2022.128662
Keywords
Cu7S4 nanosheets; Facet dependence; Theoretical computation; Antibacterial activity; Photodynamic; Photothermal therapy
Categories
Funding
- National Natural Science Foundation of Tianjin, Tianjin Science and Technology Support Key Projects [20JCYBJC01420]
- Tianjin science and technology support key projects [18YFZCSF00500]
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The surface arrangements of nanomaterials can regulate their electronic structure, and in this study, Cu7S4 nanosheets with different exposed facets were synthesized and their antibacterial activity was measured. The Cu7S4 nanosheets with (224) exposed facet exhibited excellent antibacterial activity through synergetic photodynamic and photothermal therapy against various bacteria under near-infrared light irradiation. The findings provide an efficient antibacterial strategy and advance the method of designing highly effective antibacterial nanomaterials through facet engineering.
The surface arrangements of nanomaterials can regulate their electronic structure, which will tune physico-chemical properties of materials to various applications. In this study, two Cu7S4 nanosheets with (304) and (224) exposed facets were synthesized, respectively, and their antibacterial activity of different facets for replacing antibiotics to solve seriously drug-resistant bacteria were further measured. Experimental and theoretical computation results unveiled that Cu7S4 with (224) exposed facet exhibited excellent antibacterial activity through synergetic photodynamic and photothermal therapy against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli and drug-resistant Pseudomonas aeruginosa under near-infrared light (808 nm) irradiation. Furthermore, the antibacterial agents strongly inhibit mouse skin infection by drug-resistant Pseudomonas aeruginosa cells. The findings provide an efficient antibacterial strategy and might advance the method of designing and producing highly effective antibacterial nanomaterials through facet engineering.
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