4.7 Article

Kindlin-2-miR-1258-TCF4 feedback loop promotes hepatocellular carcinoma invasion and metastasis

Related references

Note: Only part of the references are listed.
Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

Review Pharmacology & Pharmacy

Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders

Michal Caspi et al.

Summary: The Wnt pathway plays a crucial role in regulating embryogenic developmental processes and tissue homeostasis via beta-catenin. Dysregulation of this pathway has been implicated in carcinogenesis, particularly in colorectal cancer. While the Wnt cascade is an attractive target for therapeutic intervention against CRC, its complexity and challenges need to be addressed for effective treatment.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Oncology

circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway

Wei Zhang et al.

Summary: A study discovered a novel circRNA, Hsa_circ_0000847 (circ_SMAD2), which is upregulated in colorectal cancer (CRC) and positively correlates with clinical features of CRC. Functional assays showed that circ_SMAD2 promotes CRC cell invasion, proliferation, and tumor growth by increasing Ribophorin II (RPN2) levels through inhibition of miR-1258, suggesting it as a potential indicator for CRC progression.

JOURNAL OF CANCER (2021)

Article Biochemistry & Molecular Biology

The β-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 axis promotes hepatocellular carcinoma metastasis

Wei-Juan Huang et al.

ONCOGENE (2020)

Review Oncology

Role of Kindlin-2 in cancer progression and metastasis

Wei Wang et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

Review Cell Biology

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

Thomas Treiber et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Cell Biology

Integrin activation by talin, kindlin and mechanical forces

Zhiqi Sun et al.

NATURE CELL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Kindlins: Roles in development and cancer progression

Jun Zhan et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Kindlin-2 interacts with and stabilizes DNMT1 to promote breast cancer development

Peng Wang et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

Article Oncology

Kindlin-2 promotes hepatocellular carcinoma invasion and metastasis by increasing Wnt/β-catenin signaling

Jie Lin et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

Article Multidisciplinary Sciences

Structural basis of kindlin-mediated integrin recognition and activation

Huadong Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Pathology

Kindlin-2: A novel prognostic biomarker for patients with hepatocellular carcinoma

Yong-Sheng Ge et al.

PATHOLOGY RESEARCH AND PRACTICE (2015)

Article Biochemistry & Molecular Biology

A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells

Jianchao Gao et al.

FEBS LETTERS (2013)

Article Biochemistry & Molecular Biology

Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling

Yu Yu et al.

EMBO REPORTS (2012)