Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 257, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2022.109989
Keywords
Green solvent; N-Benzylation; DFT Studies; Room temperature reaction; synthesis of different regioisomers
Categories
Funding
- Aragen Life SciencesPvt. Ltd
- University Grants Commission (UGC) -India [F.20-1 (28) /2012 (BSR)]
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This study reports a method for synthesizing novel compounds based on the principles of green chemistry and using renewable solvents, resulting in high yields.
The current work reports the synthesis of novel tetracyclic N-benzylated benzopiperazine fused acridone regioisomers tagged with three trifluoromethyl and three fluoride substituents. The novelty of this work is based on the execution of green chemical principles, 2-MeTHF (2-Methyl Tetrahydrofuran) was employed as renewable solvent during this benzylation reaction (carried out at room temperature) resulting higher yields (87-94%) under halogenated solvent free methodology. The optimized reaction consists of 1.0 equivalent of compound benzopiperazine fused acridone, 1.5 equivalents of compound appropriate benzyl bromide, 2.0 equivalents of KH, 2-MeTHF solvent (5ml with respect to 1mmol of compound 1).
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