Regio- as well as stereoselective epoxide ring opening reactions using 3,3,3-trifluoroprop-1-yne

Utilization of 3,3,3-trifluoroprop-1-yne for the regio-as well as stereoselective ring opening of a variety of epoxides by the assistance of BF3 center dot & nbsp;OEt2 was demonstrated which successfully furnished the corresponding CF3- containing homopropargylic alcohols in good to excellent yields.

Automated summary

The utilization of 3,3,3-trifluoroprop-1-yne in the presence of BF3·OEt2 was demonstrated to achieve regio- and stereoselective ring opening of various epoxides, leading to the synthesis of CF3-containing homopropargylic alcohols in high yields.