Describing a modern therapeutic drug prepared by in situ decorated gold nanoparticles on starch-modified magnetic nanoparticles to treat the cutaneous wound: a preclinical trial study

In recent days, the green synthesized nanomagnetic biocomposites have been evolved with tremendous potential as the future catalysts. This has encouraged us to design and synthesis of a novel Au NP fabricated starch functionalized core-shell type nanomaterial (Fe3O4/Starch-Au nanocomposite). It was meticulously characterized using advanced analytical techniques like FT-IR, FESEM, TEM, EDX, VSM, XRD and ICP-OES. MTT assay was used on common normal cell line i.e. Human umbilical vein endothelial cells (HUVEC) to survey the cytotoxicity effects of Fe3O4/Starch-Au nanocomposite. In the part of cutaneous wound healing, use of Fe3O4/Starch-Au nanocomposite ointment, significantly (p <= 0.01) raised the wound contracture, vessel, hydroxyl proline, hexuronic acid, fibrocyte, fibroblast, and fibrocytes/fibroblast rate and significantly (p <= 0.01) decreased the wound area, total cells, neutrophil, and lymphocyte compared to other groups in rats. Finally, the results showed the useful cutaneous wound healing properties of Fe3O4/Starch-Au nanocomposite. Maybe significant cutaneous wound healing potentials of Fe3O4/Starch-Au nanocomposite are related to their antioxidant activities. For investigating the antioxidant activities of Fe3O4/Starch-Au nanocomposite, the DPPH test was used in the presence of butylated hydroxytoluene as the positive control. The Fe3O4/Starch-Au nanocomposite inhibited half of the DPPH molecules in the concentration of 156 mu g/mL.

Automated summary

In recent days, there has been significant potential found in green synthesized nanomagnetic biocomposites as future catalysts. This study focuses on the design and synthesis of a new Fe3O4/Starch-Au nanocomposite, which has been characterized using advanced analytical techniques. The results show that the Fe3O4/Starch-Au nanocomposite has beneficial properties for cutaneous wound healing, potentially due to its antioxidant activities.