Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 289, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2022.115003
Keywords
Cytotoxicity; Flavonoids; Medicinal plants; Mitotic index; Phytochemistry; Triterpenoids
Categories
Funding
- Brazilian funding Agency Fundacao de Amparo a pesquisa do Estado do RS (FAPERGS)
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This study evaluated the cytotoxic and genotoxic potential of Lantana fucata extracts and characterized them chemically. The results showed that the extracts had cytotoxic effects, especially the hydroalcoholic extract. Chromatography analysis revealed a higher abundance of flavonoids and triterpenoids in the hydroalcoholic extract, suggesting that these compounds may be responsible for its greater toxicity. Therefore, moderate consumption of L. fucata is suggested.
Ethnopharmacological relevance: One of the most popular plants used to treat diseases in Brazil is Lantana fucata. Like most herbal medicines, its consumption is based on popular knowledge, which, despite being considered effective, may cause side effects. Aim of the study: Since the scientific data on the pharmacological properties of L. fucata are still incipient, this research aimed to evaluate the cytotoxic and genotoxic potential of different types of extracts (infusion, aqueous and hydroalcoholic), characterizing them chemically. Materials and methods: The cytotoxicity assay was performed by the A. cepa model. The cytotoxicity parameters studied were number of dividing cells and percentage mitotic index (%MI). Results: The result of the A. cepa assay showed that there was a decrease in the number of dividing cells and the percentage mitotic index as concentrations increased, for all extracts, indicating cytotoxicity. However, the hydroalcoholic extract was the most cytotoxic. Chromatography analysis allowed the characterization of secondary metabolites in the extracts, which were very similar. However, a greater abundance of flavonoids and triterpenoids was observed in the hydroalcoholic extract, suggesting that these compounds are responsible for its greater toxicity. Conclusions: Since the highest doses of extracts showed to have a cytotoxic effect, it is suggested that the ingestion of this species occurs in a moderate way.
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