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INTERNATIONAL JOURNAL OF CANCER (2011)
Carbonic anhydrase IX (CA9) modulates tumor-associated cell migration and invasion
Hye-Jin Shin et al.
JOURNAL OF CELL SCIENCE (2011)
Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis
Fabio Pacchiano et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment
Jonathan W. Wojtkowiak et al.
MOLECULAR PHARMACEUTICS (2011)
Differential Impact of EGFR-Targeted Therapies on Hypoxia Responses: Implications for Treatment Sensitivity in Triple-Negative Metastatic Breast Cancer
Abderrahim El Guerrab et al.
PLOS ONE (2011)
Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation
Ludwig Dubois et al.
RADIOTHERAPY AND ONCOLOGY (2011)
A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREXA®) and interferon-alpha-2a in metastatic renal cell carcinoma patients
M. Siebels et al.
WORLD JOURNAL OF UROLOGY (2011)
Dysregulated pH: a perfect storm for cancer progression
Bradley A. Webb et al.
NATURE REVIEWS CANCER (2011)
Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target
Giuseppina De Simone et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)
The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis
Kristiina Nordfors et al.
BMC CANCER (2010)
Modulation of Carbonic Anhydrase 9 (CA9) in Human Brain Cancer
Harun M. Said et al.
CURRENT PHARMACEUTICAL DESIGN (2010)
Carbonic Anhydrase IX as an Anticancer Therapy Target: Preclinical Evaluation of Internalizing Monoclonal Antibody Directed to Catalytic Domain
M. Zatovicova et al.
CURRENT PHARMACEUTICAL DESIGN (2010)
Carbonic Anhydrase IX in Renal Cell Carcinoma: Implications for Prognosis, Diagnosis, and Therapy
Alexander B. Stillebroer et al.
EUROPEAN UROLOGY (2010)
Selective Inhibition of Carbonic Anhydrase IX Decreases Cell Proliferation and Induces Ceramide-Mediated Apoptosis in Human Cancer Cells
Fabio Cianchi et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)
The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes
Arnold J. Levine et al.
SCIENCE (2010)
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian α-carbonic anhydrase isoforms
Seppo Parkkila et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives
Julia K. J. Ahlskog et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH
Johanna Chiche et al.
CANCER RESEARCH (2009)
HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress
Seong-Hee Lee et al.
CARCINOGENESIS (2009)
Intact intracellular tail is critical for proper functioning of the tumor-associated, hypoxia-regulated carbonic anhydrase IX
Alzbeta Hulikova et al.
FEBS LETTERS (2009)
Cyclooxygenase-2/carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells
Pasquale Sansone et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)
Generating specificity and diversity in the transcriptional response to hypoxia
Urban Lendahl et al.
NATURE REVIEWS GENETICS (2009)
Hypoxia-associated p38 mitogen-activated protein kinase-mediated androgen receptor activation and increased HIF-1α levels contribute to emergence of an aggressive phenotype in prostate cancer
L. Khandrika et al.
ONCOGENE (2009)
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
William G. Kaelin et al.
MOLECULAR CELL (2008)
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
Claudiu T. Supuran
NATURE REVIEWS DRUG DISCOVERY (2008)
Molecular Origins of Cancer Molecular Basis of Metastasis
Anne C. Chiang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: Kinetic and X-ray crystallographic studies
Claudia Temperini et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Genetic determinants of cancer metastasis
Don X. Nguyen et al.
NATURE REVIEWS GENETICS (2007)
Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumours
P. Hynninen et al.
HISTOPATHOLOGY (2006)
Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1α signal pathways increases resistance to apoptosis by up-regulating survivin gene expression
Xiang-Hong Peng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Carbonic anhydrase IX expression and tumor oxygenation status do not correlate at the microregional level in locally-advanced cancers of the uterine cervix
A Mayer et al.
CLINICAL CANCER RESEARCH (2005)
Hypoxia-induced dedifferentiation of tumor cells -: A mechanism behind heterogeneity and aggressiveness of solid tumors
H Axelson et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2005)
Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer
K Smith et al.
CANCER RESEARCH (2005)
A phase II trial of chimeric monoclonal antibody G250 for advanced renal cell carcinoma patients
I Bleumer et al.
BRITISH JOURNAL OF CANCER (2004)
Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: New pharmacological opportunities due to related binding site recognition
A Weber et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion
N Robertson et al.
CANCER RESEARCH (2004)
CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion
LYW Bourguignon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors
JY Winum et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300
NL Sang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides
D Vullo et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin
E Svastova et al.
EXPERIMENTAL CELL RESEARCH (2003)
Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9
MO Gut et al.
GASTROENTEROLOGY (2002)
Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma
SK Chia et al.
JOURNAL OF CLINICAL ONCOLOGY (2001)
CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration
LYW Bourguignon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)