Journal
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 37, Issue 1, Pages 1278-1298Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756366.2022.2052868
Keywords
Cancer; carbonic anhydrase; inhibitor; sulphonamides
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Carbonic anhydrases IX and CAXII play crucial roles in cancer and have become a focus in anticancer drug design. This offers an opportunity to develop new targeted therapies with fewer side effects.
Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide into bicarbonate with a release of the proton. CA, especially CAIX and CAXII isoforms gained the attention of many researchers interested in anticancer drug design due to pivotal functions of enzymes in the cancer cell metastasis and response to hypoxia, and their expression restricted to malignant cells. This offers an opportunity to develop new targeted therapies with fewer side effects. Continuous efforts led to the discovery of a series of diverse compounds with the most abundant sulphonamide derivatives. Here we review current knowledge considering small molecule and antibody-based targeting of CAIX/CAXII in cancer.
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