Quantifying exposure source allocation factors of pesticides in support of regulatory human health risk assessment

One of the challenges while assessing the aggregate exposure risk of pesticides is quantifying exposure doses from various exposure pathways. To address this issue, a regulatory screening approach is proposed for evaluating pesticide allocation factors (AFs) for major exposure pathways for rural and urban residents. This was achieved by integrating dynamiCrop and other screening models to estimate the potential human intake of residues from major crops at harvest, livestock products, and main environmental media (air, water, and soil). The AFs were calculated from the average daily dose factors (ADDFs) of pesticides via major exposure pathways, where a large AF of an exposure pathway indicates that a greater margin of exposure should be given to that exposure pathway. The simulated results for many current-use pesticides showed that the ingestion of crops had pesticide AFs close to 1.0, which indicated that the crop exposure pathway contributed to a significant portion of the total exposure to pesticides. In contrast, for legacy pesticides with high lipophilicity and low degradability in the environment, the simulated AFs for major environmental compartments (air, freshwater, and soil) accounted for relatively large exposures. As legacy pesticides have been banned globally, exposure pathways via the food web and environmental media cannot be neglected because of their high lipophilicity and environmental persistence. Although other factors such as geographical conditions and living habits should be considered to improve the spatial resolution of the model, the method proposed in this study can serve as a preliminary tool to conduct screening-level risk assessments for populations by considering the allocated exposure to pesticides via major exposure pathways.

Automated summary

This study proposes a regulatory screening approach to evaluate pesticide allocation factors (AFs) for different exposure pathways. By integrating various models, the study estimates the human intake of pesticide residues from crops, livestock products, and environmental media. The results show that crop exposure contributes significantly to pesticide exposure, while legacy pesticides with high lipophilicity and low degradability mainly expose through environmental compartments.