Journal
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Volume 71, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jddst.2022.103277
Keywords
Propionibacterium acnes ( P; acnes ); Cutibacterium acnes ( C; comedolytic; biocompatible; topical delivery
Categories
Ask authors/readers for more resources
A new microemulsion-based topical treatment containing hydrogen-loaded isotretinoin and erythromycin estolate has been developed for acne management, showing promising drug permeation and skin retention effects in experiments.
Acne is a youth and many adults problem that hampers their social life and self-esteem. Numerous unknown underlying factors, including the Cutibacterium acnes (C. acnes) infection, lead to acne. The present study presents a novel platform of microemulsion-based topical hydrogen loaded with isotretinoin and erythromycin estolate to manage acne. The developed system was in the nanometric range (79.45 nm) with a polydispersity index (PDI) of 0.192. The developed microemulsion and the hydrogel exhibited the desired Newtonian flow characteristics. The permeation of the drugs across the rodent skin was substantially higher than the marketed/ conventional product. The developed system offered substantial skin retention to both drugs, the desired attribute for acne treatment. The in-vitro studies on C. acnes vouched for the enhanced efficacy of the developed system vis-`a-vis the plain erythromycin estolate and clindamycin as the standard. The findings are promising as the topical use of erythromycin estolate with isotretinoin is established for the first time, along with the synergism. The simple, safer and effective nanoformulation inherits the potential to manage acne in a better way.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available