4.6 Article

Optimizing a Deep Residual Neural Network with Genetic Algorithm for Acute Lymphoblastic Leukemia Classification

Journal

JOURNAL OF DIGITAL IMAGING
Volume 35, Issue 3, Pages 623-637

Publisher

SPRINGER
DOI: 10.1007/s10278-022-00600-3

Keywords

Leukemia classification; Convolutional neural networks; Genetic algorithm; Hyperparameter optimization; Fine-tuning

Funding

  1. CNPq [307100/2021-9, 311022/2018-9]
  2. CoordenacAo de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]

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This paper introduces a hybrid model using genetic algorithms and residual convolutional neural networks for ALL prediction, which improves the accuracy of the classifier. The study suggests that computer vision-based approaches have potential applications in leukemia identification.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer worldwide, and it is characterized by the production of immature malignant cells in the bone marrow. Computer vision techniques provide automated analysis that can help specialists diagnose this disease. Microscopy image analysis is the most economical method for the initial screening of patients with ALL, but this task is subjective and time-consuming. In this study, we propose a hybrid model using a genetic algorithm (GA) and a residual convolutional neural network (CNN), ResNet-50V2, to predict ALL using microscopy images available in ALL-IDB dataset. However, accurate prediction requires suitable hyperparameters setup, and tuning these values manually still poses challenges. Hence, this paper uses GA to find the best hyperparameters that lead to the highest accuracy rate in the models. Also, we compare the performance of GA hyperparameter optimization with Random Search and Bayesian optimization methods. The results show that GA optimization improves the accuracy of the classifier, obtaining 98.46% in terms of accuracy. Additionally, our approach sheds new perspectives on identifying leukemia based on computer vision strategies, which could be an alternative for applications in a real-world scenario.

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