Journal
JOURNAL OF DERMATOLOGICAL TREATMENT
Volume 33, Issue 5, Pages 2587-2592Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546634.2022.2049588
Keywords
Atopic dermatitis; dupilumab; type 2 inflammation; eosinophils
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Transient eosinophilia is common in patients with moderate-to-severe atopic dermatitis treated with dupilumab. Patients with a history of conjunctivitis, food allergies, facial redness dermatitis, or dupilumab-induced ocular surface disease experience significant increases in absolute eosinophil count at 4 months.
Introduction Transient eosinophilia is not uncommon in patients with moderate-to-severe atopic dermatitis (AD) treated with dupilumab. Methods A retrospective, single center, observational study was conducted to assess the difference in terms of absolute eosinophil count (AEC) change at 4 months and at 12 months, relative to the baseline, in predefined subgroups of patients affected by moderate-to-severe AD treated with dupilumab. Results Complete data for 373, 289 and 210 patients were available at the baseline, 4 months and 12 months, respectively. Patients with a history of conjunctivitis (n = 152) had greater increases in AEC at 4 months as compared with those (n = 137) who did not (+16%vs0%,p = 0.01). Patients with food allergies (n = 46) showed similar increases (+39%vs + 5%, p = 0.01). Patients experiencing facial redness dermatitis on dupilumab (n = 46) had greater increases in AEC at 4 months than those (n = 243) who did not (+40%vs + 5%, p = 0.03). Patients that had dupilumab-induced ocular surface disease (n = 44) had greater increases in AEC at 4 months than those (n = 245) who did not (+43%vs + 5%, p = 0.01). Conclusions Atopic comorbidities are associated with a paradoxical increase in AEC at 4 months in AD patients treated with dupilumab. Patients experiencing dupilumab-related ocular surface disease or facial redness dermatitis also have remarkable increases in AEC at 4 months.
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