Evaluating the in vitro efficacy of bovine lactoferrin products against SARS-CoV-2 variants of concern

Article Nutrition & Dietetics

Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro

Claudio Salaris et al.

Summary: The study indicates that lactoferrin may help prevent SARS-CoV-2 infection in vitro by inducing the expression of antiviral immune response genes and partially inhibiting viral replication.

NUTRIENTS (2021)

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Article Biochemistry & Molecular Biology

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

Piyada Supasa et al.

Summary: Research on the UK-dominant variant B.1.1.7 shows that it is harder to neutralize than the parental virus, but widespread escape from antibodies or monoclonal antibodies has not been observed yet.

CELL (2021)

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Review Immunology

The potential for Lactoferrin to reduce SARS-CoV-2 induced cytokine storm

Michal Zimecki et al.

Summary: The COVID-19 pandemic, caused by SARS-CoV-2, poses a serious global health threat with cytokine storm being a major factor in mortality. Lactoferrin has shown potential in suppressing cytokine storm and could be a promising approach in combating COVID-19 infection.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England

Nicholas G. Davies et al.

Summary: A new variant of SARS-CoV-2 has emerged in England, with a higher reproduction number and potential for large resurgences of COVID-19 cases. Without stringent control measures, it is projected that COVID-19 hospitalizations and deaths in England for the first 6 months of 2021 will exceed those in 2020. The variant has spread globally and exhibited similar transmission increases in Denmark, Switzerland, and the United States.

SCIENCE (2021)

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Article Medicine, General & Internal

Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study

Robert Challen et al.

Summary: The study found that the mortality hazard ratio associated with infection with VOC-202012/1 compared with previously circulating variants was 1.64, indicating an increase in deaths from 2.5 to 4.1 per 1000 detected cases in comparatively low risk group of covid-19 patients in the community. This suggests that infection with VOC-202012/1 may lead to substantial additional mortality compared with previously circulating variants, impacting healthcare capacity planning and control policies.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Microbiology

Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern

Nariman Shahhosseini et al.

Summary: One year after the outbreak of the COVID-19 pandemic, various new variants have emerged globally, with some showing increased transmissibility or infectivity. Studies have identified different mutations in the receptor-binding domain (RBD) of these variants, affecting their affinity for human angiotensin-converting enzyme 2 (hACE2). Genomic surveillance should be enhanced to detect and monitor new variants promptly.

MICROORGANISMS (2021)

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Article Multidisciplinary Sciences

Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19

Carmen Mirabelli et al.

Summary: Drug repurposing is an effective method for rapidly identifying drugs against SARS-CoV-2. Research has found that lactoferrin can inhibit virus infection in multiple cell models, showing potential for treating COVID-19.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Biochemistry & Molecular Biology

COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeutics

Dmitry Tworowski et al.

Summary: The recent outbreak of COVID-19 has generated a large amount of Big Data, which researchers analyze to provide new opportunities for the successful application of currently approved therapeutics and their combinations for conditions caused by a novel SARSCoV-2 infection. Effective responses to the pandemic require the development of efficient applications, methods, and algorithms for data analysis and reasoning.

NUCLEIC ACIDS RESEARCH (2021)

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Article Immunology

The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor

Yanmei Hu et al.

Summary: The study highlights the important role of HSPGs in SARS-CoV-2 cell attachment, and demonstrates the broad-spectrum antiviral activity of LF against various coronaviruses, especially with BLF being more potent than HLF. BLF binds to HSPGs to block viral attachment, and its antiviral activity can be antagonized by the HSPG mimetic heparin. Combination therapy experiment shows synergistic effect of LF with remdesivir in cell culture.

EMERGING MICROBES & INFECTIONS (2021)

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Letter Infectious Diseases

An interactive web-based dashboard to track COVID-19 in real time

Ensheng Dong et al.

LANCET INFECTIOUS DISEASES (2020)

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Editorial Material Surgery

COVID-19 pandemic: perspectives on an unfolding crisis

A. Spinelli et al.

BRITISH JOURNAL OF SURGERY (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

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Review Biochemistry & Molecular Biology

Lactoferrin's Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action

Antimo Cutone et al.

BIOMOLECULES (2020)

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Article Infectious Diseases

Lactoferrin as potential preventative and adjunct treatment for COVID-19

Raymond Chang et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

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Article Medicine, General & Internal

Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19 A Randomized Clinical Trial

Christoph D. Spinner et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Virology

Coronavirus Antiviral Research Database (CoV-RDB): An Online Database Designed to Facilitate Comparisons between Candidate Anti-Coronavirus Compounds

Philip L. Tzou et al.

VIRUSES-BASEL (2020)

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Review Engineering, Biomedical

Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand

Ahmed O. Elzoghby et al.

BIOMATERIALS (2020)

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Review Medicine, Research & Experimental

Lactoferrin for the treatment of COVID-19 (Review)

Yidan Wang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

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Review Medicine, Research & Experimental

Multifunctional capacity and therapeutic potential of lactoferrin

Luis Moreno-Exposito et al.

LIFE SCIENCES (2018)

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Article Biochemistry & Molecular Biology

CellProfiler 3.0: Next-generation image processing for biology

Claire McQuin et al.

PLOS BIOLOGY (2018)

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Review Biochemistry & Molecular Biology

Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis

Luigi Rosa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Review Chemistry, Multidisciplinary

Immunomodulatory effects of lactoferrin

Tania Siqueiros-Cendon et al.

ACTA PHARMACOLOGICA SINICA (2014)

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Article Biology

Potential lactoferrin activity against pathogenic viruses

Elrashdy M. Redwan et al.

COMPTES RENDUS BIOLOGIES (2014)

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Review Infectious Diseases

Lactoferrin for prevention of common viral infections

Hiroyuki Wakabayashi et al.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2014)

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Review Immunology

Sequestration and Scavenging of Iron in Infection

Nermi L. Parrow et al.

INFECTION AND IMMUNITY (2013)

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Article Multidisciplinary Sciences

Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

Jianshe Lang et al.

PLOS ONE (2011)

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Article Biochemistry & Molecular Biology

A critical review of the roles of host lactoferrin in immunity

Dominique Legrand et al.

BIOMETALS (2010)

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Article Obstetrics & Gynecology

Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: A prospective controlled randomized study

Carmine Nappi et al.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2009)

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Review Biochemistry & Molecular Biology

Antimicrobial properties of lactoferrin

Havard Jenssen et al.

BIOCHIMIE (2009)

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Article Pediatrics

Does daily intake of bovine lactoferrin-containing products ameliorate rotaviral gastroenteritis?

Masanori Egashira et al.

ACTA PAEDIATRICA (2007)

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Review Food Science & Technology

Antiviral properties of milk proteins and peptides

Y. Pan et al.

INTERNATIONAL DAIRY JOURNAL (2006)

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Review Biochemistry & Molecular Biology

Lactoferrin: an important host defence against microbial and viral attack

P Valenti et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2005)

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Review Biochemistry & Molecular Biology

Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties

JL Gifford et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2005)

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Review Pharmacology & Pharmacy

Antiviral activities of lactoferrin

BWA van der Strate et al.

ANTIVIRAL RESEARCH (2001)

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Evaluating the in vitro efficacy of bovine lactoferrin products against SARS-CoV-2 variants of concern

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