Journal
JOURNAL OF COORDINATION CHEMISTRY
Volume 75, Issue 3-4, Pages 448-456Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00958972.2022.2053846
Keywords
Triazole; phthalocyanine; singlet oxygen; fluorescence quenching; photosensitizer
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The researchers synthesized and characterized the phthalonitrile and phthalocyanine derivatives, and studied their solubility and photophysical and photochemical behaviors in organic solvents. They found that zinc(II) phthalocyanine has potential as a photosensitizer for photodynamic therapy.
Phthalonitrile (3) including 4-(4-fluorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazole-3-thio substituent and its peripherally tetra substituted metal-free (4), zinc(II) (5) and lead(II) (6) phthalocyanine derivatives were prepared and characterized by FTIR, mass, H-1-NMR and C-13-NMR spectroscopic data. All studied phthalocyanines had good solubility in common organic solvents and did not aggregate. The photophysical and photochemical behaviors of the phthalocyanine complexes (4-6) were examined in DMSO to determinate their PDT potential. Singlet oxygen, fluorescence and photodegradation quantum yields showed that zinc(II) phthalocyanine (5) has potential as Type II photosensitizer for PDT applications.
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