4.8 Article

Emerging technologies to increase gastrointestinal transit times of drug delivery systems

Related references

Note: Only part of the references are listed.
Article Chemistry, Physical

Reactive oxygen species (ROS) in colloidal systems: Are PEG-free surfactants the answer?

Julian David Friedl et al.

Summary: The study evaluated polyglycerol- and saccharide-surfactants as PEG-free alternatives for polyethylene glycol-surfactants, revealing that PEG-free-surfactants showed superior performance in addressing oxidation, ROS formation, and degradation of oxidation-prone active ingredients.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

Review Pharmacology & Pharmacy

Alkaline Phosphatase: A Reliable Endogenous Partner for Drug Delivery and Diagnostics

Bao Le-Vinh et al.

Summary: Alkaline phosphatase has been widely used in drug delivery and diagnostics. By cleaving phosphate substructures from drugs and nanocarriers, this enzyme allows drug delivery systems to change their properties in the body. It can also facilitate the accumulation of nanocarriers at target sites and trigger targeted drug release.

ADVANCED THERAPEUTICS (2022)

Article Chemistry, Applied

Inclusion complex based on N-acetyl-L-cysteine and arginine modified hydroxypropyl-β-cyclodextrin for oral insulin delivery

Siyi Li et al.

Summary: The novel NAC-HP-β-CD-Arg was successfully synthesized for oral delivery of insulin, showing protective effects against enzymatic degradation and excellent hypoglycemic effects in vivo.

CARBOHYDRATE POLYMERS (2021)

Article Pharmacology & Pharmacy

Nanoparticles facing the gut barrier: Retention or mucosal absorption? Mechanisms and dependency to nanoparticle characteristics

Christelle Zandanel et al.

Summary: This research focuses on understanding the impact of nanomedicine characteristics on their oral fate, including retention and absorption in the intestines, and highlights the importance of molecular design and formulation on how nanoparticles interact with mucosa. The data provided insights for formulators to address challenges in oral drug delivery and improve systemic delivery using the most absorbed nanoparticles.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Pharmacology & Pharmacy

PEG That Reaction: A Case Series of Allergy to Polyethylene Glycol

Fionnuala Cox et al.

Summary: This study presents 6 cases of acute hypersensitivity to PEG, all female with an average age of 36.4 years. Biphasic allergic reactions were prominent in these cases, and diagnosis relied on a high index of suspicion and focused clinical history.

JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Article Chemistry, Physical

Regular Charge reversal self-emulsifying drug delivery systems: A comparative study among various phosphorylated surfactants

Zeynep Burcu Akkus-Dagdeviren et al.

Summary: The phosphorylated surfactants with ethoxylate spacer arms are promising excipients for charge reversal self-emulsifying drug delivery systems (SEDDS), achieving charge reversal by changing their Zeta potential. The experiments also revealed a correlation between the primary amine content in the formulations, phosphate release, cytotoxicity, and cellular uptake ability of SEDDS.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

Article Biochemistry & Molecular Biology

In Vitro Investigation of Thiolated Chitosan Derivatives as Mucoadhesive Coating Materials for Solid Lipid Nanoparticles

Richard Wibel et al.

Summary: In this study, thiolated chitosan was used as a coating material for solid lipid nanoparticles, with the protection of thiol groups playing a key role in their interaction with mucosa. Different coating materials showed varying effects on mucus interaction and diffusion behavior on intestinal mucosa.

BIOMACROMOLECULES (2021)

Article Pharmacology & Pharmacy

Size shifting of solid lipid nanoparticle system triggered by alkaline phosphatase for site specific mucosal drug delivery

Bao Le-Vinh et al.

Summary: This study aimed to prepare a size-shifting nanocarrier for site-targeting mucosal drug delivery. Solid lipid nanoparticles loaded with a phosphate ester surfactant and octadecylamine were utilized, and alkaline phosphatase was used as an in situ partner for triggering the size conversion at epithelial cell surface. The developed SLN system shows potential for mucosal drug delivery to AP-expressing tissues.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2021)

Article Nanoscience & Nanotechnology

Per-6-Thiolated Cyclodextrins: A Novel Type of Permeation Enhancing Excipients for BCS Class IV Drugs

Mulazim Hussain Asim et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Pharmacology & Pharmacy

Phosphorylated PEG-emulsifier: Powerful tool for development of zeta potential changing self-emulsifying drug delivery systems (SEDDS)

Julian Dominik Wolf et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

Article Pharmacology & Pharmacy

Tetradeca-thiolated cyclodextrins: Highly mucoadhesive and in-situ gelling oligomers with prolonged mucosal adhesion

Mulazim Hussain Asim et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Article Pharmacology & Pharmacy

Zeta potential changing nanoemulsions: Impact of PEG-corona on phosphate cleavage

Sergey Zaichik et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Review Chemistry, Inorganic & Nuclear

Thiolated cyclodextrins: New perspectives for old excipients

Mulazim Hussain Asim et al.

COORDINATION CHEMISTRY REVIEWS (2020)

Review Pharmacology & Pharmacy

Thiolated polymers: Bioinspired polymers utilizing one of the most important bridging structures in nature

Christina Leichner et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

Article Medicine, Research & Experimental

Zeta Potential Changing Polyphosphate Nanoparticles: A Promising Approach To Overcome the Mucus and Epithelial Barrier

Zeynep Burcu Akkus et al.

MOLECULAR PHARMACEUTICS (2019)

Review Pharmacology & Pharmacy

Current State and Future Perspectives on Gastroretentive Drug Delivery Systems

Julu Tripathi et al.

PHARMACEUTICS (2019)

Article Biochemistry & Molecular Biology

S-protected gellan gum: Decisive approach towards mucoadhesive antimicrobial vaginal films

Aamir Jalil et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Article Chemistry, Medicinal

Design of Virus-Mimicking Polyelectrolyte Complexes for Enhanced Oral Insulin Delivery

Chang Liu et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Review Pharmacology & Pharmacy

Enzyme decorated drug carriers: Targeted swords to cleave and overcome the mucus barrier

Claudia Menzel et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Review Chemistry, Multidisciplinary

Cyclodextrins, from molecules to applications

Gregorio Crini et al.

ENVIRONMENTAL CHEMISTRY LETTERS (2018)

Article Pharmacology & Pharmacy

Synthesis of thiolated, PEGylated and POZylated silica nanoparticles and evaluation of their retention on rat intestinal mucosa in vitro

Twana Mohammed M. Ways et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

Article Nanoscience & Nanotechnology

Non-ionic thiolated cyclodextrins - the next generation

Ali Moghadamu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

Article Pharmacology & Pharmacy

Self-emulsifying peptide drug delivery systems: How to make them highly mucus permeating

Janine Griesser et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Article Chemistry, Physical

Trypsin decorated self-emulsifying drug delivery systems (SEDDS): Key to enhanced mucus permeation

Iram Shahzadi et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2018)

Article Chemistry, Physical

S-protected thiolated cyclodextrins as mucoadhesive oligomers for drug delivery

Mulazim Hussain Asim et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2018)

Article Multidisciplinary Sciences

Insights into gold nanoparticles as a mucoadhesive system

Mathieu Ouellette et al.

SCIENTIFIC REPORTS (2018)

Article Pharmacology & Pharmacy

In vivo biodistribution of antihyperglycemic biopolymer-based nanoparticles for the treatment of type 1 and type 2 diabetes

Marlene Lopes et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

Article Pharmacology & Pharmacy

About the impact of water movement on the permeation behaviour of nanoparticles in mucus

Angela Fabiano et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Article Pharmacology & Pharmacy

Development of pre-activated α-cyclodextrin as a mucoadhesive excipient for intra-vesical drug delivery

Muhammad Ijaz et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Article Nanoscience & Nanotechnology

Influence of Particle Geometry on Gastrointestinal Transit and Absorption following Oral Administration

Dong Li et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Review Biochemistry & Molecular Biology

The Prodrug Approach: A Successful Tool for Improving Drug Solubility

Daniela Hartmann Jornada et al.

MOLECULES (2016)

Article Pharmacology & Pharmacy

Development and in vitro evaluation of zeta potential changing self-emulsifying drug delivery systems for enhanced mucus permeation

Wongsakorn Suchaoin et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

Article Chemistry, Medicinal

Thiolated Cyclodextrin: Development of a Mucoadhesive Vaginal Delivery System for Acyclovir

Muhammad Ijaz et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2016)

Article Chemistry, Medicinal

Thiolated α-Cyclodextrin: The Invisible Choice to Prolong Ocular Drug Residence Time

Muhammad Ijaz et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2016)

Article Chemistry, Multidisciplinary

Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues

Miaorong Yu et al.

NANO LETTERS (2016)

Article Chemistry, Multidisciplinary

Evidence does not support absorption of intact solid lipid nanoparticles via oral delivery

Xiongwei Hu et al.

NANOSCALE (2016)

Article Pharmacology & Pharmacy

Mucus permeating thiomer nanoparticles

S. Koellner et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

Article Pharmacology & Pharmacy

Nanoparticles decorated with proteolytic enzymes, a promising strategy to overcome the mucus barrier

Irene Pereira de Sousa et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

Article Pharmacology & Pharmacy

Development of phosphorylated nanoparticles as zeta potential inverting systems

Glen Perera et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

Article Pharmacology & Pharmacy

Mucus permeating carriers: formulation and characterization of highly densely charged nanoparticles

Irene Pereira de Sousa et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

Article Pharmacology & Pharmacy

In vivo study of the mucus-permeating properties of PEG-coated nanoparticles following oral administration

Laura Inchaurraga et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

Article Pharmacology & Pharmacy

Polyethylene imine-6-phosphogluconic acid nanoparticles - a novel zeta potential changing system

Sonja Bonengel et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

Article Multidisciplinary Sciences

Subdiffusive motion of bacteriophage in mucosal surfaces increases the frequency of bacterial encounters

Jeremy J. Barr et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Pharmacology & Pharmacy

Development and in vivo evaluation of papain-functionalized nanoparticles

Christiane Mueller et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)

Article Chemistry, Medicinal

Mucoadhesive Tablets for Controlled Release of Acyclovir

Roberto Ruiz-Caro et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2012)

Article Medicine, General & Internal

Bowel Obstruction due to Migration of an Intragastric Balloon Necessitating Surgical Removal before Completion of the Recommended 6 Months

Seyed Morteza Mousavi Naeini et al.

CASE REPORTS IN MEDICINE (2012)

Review Chemistry, Applied

Gastroretentive microparticles for drug delivery applications

Adeola Adebisi et al.

JOURNAL OF MICROENCAPSULATION (2011)

Article Chemistry, Multidisciplinary

Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery

Jie Shen et al.

JOURNAL OF CONTROLLED RELEASE (2009)

Review Biotechnology & Applied Microbiology

Cyclodextrin-based pharmaceutics: Past, present and future

ME Davis et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

Review Chemistry, Multidisciplinary

Expandable gastroretentive dosage forms

EA Klausner et al.

JOURNAL OF CONTROLLED RELEASE (2003)

Article Biophysics

Diffusion of macromolecules and virus-like particles in human cervical mucus

SS Olmsted et al.

BIOPHYSICAL JOURNAL (2001)