Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 610, Issue -, Pages 621-633Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2021.11.108
Keywords
zinc-doped Prussian blue; Photothermal; Biosafety; Antibacterial; Wound healing
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Funding
- National Natural Science Foundation of China [21874102, 22074109, 21775114]
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The finely-designed nanocomposites CuS@Au@ZnPBA exhibit excellent photothermal properties and biosafety, effectively killing bacteria and accelerating wound healing, making them a promising antibacterial alternative.
Bacteria-infected wounds have imposed serious challenges in human health whereas the abuse of antibiotics makes bacteria drug-resistant and becoming more and more difficult to deal with. Herein, we developed a drug-free three-layered photothermal bactericide from inside to outside consisting of copper sulfide (CuS), gold (Au) and zinc-doped Prussian blue analogues (ZnPBA) (named as CuS@Au@ZnPBA). The CuS@Au@ZnPBA was demonstrated to possess remarkably-improved photothermal property and excellent biosafety. Local heat generated by CuS@Au@ZnPBA under the irradiation of 808 nm laser enables efficient bacteria ablation in vitro and in a mouse model of cutaneous wound infection. Meanwhile, the released zinc ions (Zn2+) could upregulate the genes involved in collagen deposition to accelerate wound healing. Overall, the finely-designed nanocomposites can serve as a promising kind of antibacterial alternative to current antibiotic therapies against bacterial wound infections. (C) 2021 Elsevier Inc. All rights reserved.
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