Thermosensitive and tum or microenvironment activated nanotheranostics for the chemodynamic/photothermal therapy of colorectal tumor

This research proposes the one-pot preparation of polydopamine (PDA) decorated mesoporous silica nanoparticle (PMSN) for the thermal and tumor micro-environment (TME) responsive colorectal tumor therapy. The pores of PMSN were used for the Fe3+ loading. Lauric acid (LA), a phase-change ligand, was selected as a doorkeeper to coat the surface of Fe3+-loaded PMSN and prevent the undesired leakage of Fe3+. Bovine serum albumin (BSA) was selected as a stabilizer to endow the PMSN-Fe-LA-BSA nanopartilces (PMFLB) with colloidal stability. Under the near infrared laser, the light-sensitive PDA produced significant heat to kill the colorectal cancer cells via hyperthermia. Moreover, the heat induced the phase-change of LA and triggered the release of Fe3+, which further reacted with the endogenous H2S in the colorectal TME. After that, the Fe3+ was transformed into Fe2+, which triggered the Fenton reaction with the H2O2 in the TME and effectively generated hydroxyl radical (center dot OH). Finally, the Fe2+ was transformed into Fe3+, which repeatedly reacted with the H2S and produced more center dot OH to enhance the chemodynamic therapy of colorectal tumor. Such a thermosensitive PMFLB which operates in synergy with the colorectal TME opens an alternative avenue for the rational design of multifunctional nano-therapeutic agents. (c) 2021 Elsevier Inc. All rights reserved.

Automated summary

This research proposes the one-pot preparation of polydopamine (PDA) decorated mesoporous silica nanoparticle (PMSN) for the thermal and tumor micro-environment (TME) responsive colorectal tumor therapy. The PMSN pores were utilized for loading Fe3+. Lauric acid (LA) was selected as a phase-change ligand to coat the surface of Fe3+-loaded PMSN and prevent the leakage of Fe3+. Bovine serum albumin (BSA) was chosen as a stabilizer to provide colloidal stability for the PMSN-Fe-LA-BSA nanopartilces (PMFLB). Under near infrared laser, the light-sensitive PDA generated heat to kill colorectal cancer cells via hyperthermia. The heat induced the phase-change of LA and triggered the release of Fe3+, which reacted with endogenous H2S in the colorectal TME. The transformed Fe3+ into Fe2+ then initiated the Fenton reaction with H2O2, generating hydroxyl radical (•OH). The Fe2+ was converted back to Fe3+, which further reacted with H2S to enhance the chemodynamic therapy of colorectal tumor. The thermosensitive PMFLB that operates in synergy with the colorectal TME offers a new approach for the rational design of multifunctional nano-therapeutic agents.