Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 137, Issue 6, Pages 1631-1645Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2016.04.009
Keywords
IgE; mast cells; anaphylaxis
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Funding
- NIAID NIH HHS [R01 AI119918, T32 AI007512] Funding Source: Medline
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Fifty years ago, after a long search, IgE emerged as the circulating factor responsible for triggering allergic reactions. Its extremely low concentration in plasma created significant hurdles for scientists working to reveal its identity. We now know that IgE levels are invariably increased in patients affected by atopic conditions and that IgE provides the critical link between the antigen recognition role of the adaptive immune system and the effector functions of mast cells and basophils at mucosal and cutaneous sites of environmental exposure. This review discusses the established mechanisms of action of IgE in pathologic immediate hypersensitivity, as well as its multifaceted roles in protective immunity, control of mast cell homeostasis, and its more recently revealed immunomodulatory functions. (J Allergy Clin Immunol 2016; 137:1631-45.)
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